Performance of the EQ-5D-5L Plus Respiratory Bolt-On in the Birmingham Chronic Obstructive Pulmonary Disease Cohort Study

EJI (Martine) Hoogendoorn - Lips*, Susan Jowett, Andrew P. Dickens, Rachel Jordan, Alexandra Enocson, Peymane Adab, MM (Matthijs) Versteegh, MPMH (Maureen) Rutten - van Molken

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
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A respiratory bolt-on dimension for the EQ-5D-5L has recently been developed and valued by the general public. This study aimed to validate the EQ-5D-5L plus respiratory dimension (EQ-5D-5L+R) in a large group of patients with chronic obstructive pulmonary disease (COPD).
Validation was undertaken with data from the Birmingham COPD Cohort Study, a longitudinal UK study of COPD primary care patients. Data on the EQ-5D-5L+R were collected from 1008 responding participants during a follow-up questionnaire in 2017 and combined with (previously collected) data on patient and disease characteristics. Descriptive and correlation analyses were performed on the EQ-5D-5L+R dimensions and utilities, in relation to COPD characteristics and compared with the EQ-5D-5L without respiratory dimension. Multivariate regression models were estimated to test whether regression coefficients of clinical characteristics differed between the EQ-5D-5L+R utility and the EQ-5D-5L utility.
Correlation coefficients for the EQ-5D-5L+R utility with COPD parameters were slightly higher than the EQ-5D-5L utility. Both instruments displayed discriminant validity but analyses in clinical subgroups of patients showed larger absolute differences in utilities for the EQ-5D-5L+R. In the multivariate analyses, only the coefficient for the COPD Assessment Test score was higher for the model using the EQ-5D-5L+R utility as outcome.
This study showed that the addition of a respiratory domain to the EQ-5D-5L led to small improvements in the instrument’s performance. Comparability of the EQ-5D across diseases, currently considered one of its strengths, would have to be traded off against a modest improvement in utility difference when adding the respiratory dimension.
Original languageEnglish
Pages (from-to)1667-1675
Number of pages9
JournalValue in Health
Issue number11
Publication statusPublished - 1 Nov 2021

Bibliographical note

Funding/Support: This work was supported by grant 20190850 from the EuroQol Foundation . The paper presents independent research using the Birmingham COPD Cohort Study which is funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant Reference Number RP-PG-0109-10061). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The Birmingham COPD Cohort study is part of The Birmingham Lung Improvement StudieS – BLISS.

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