Perioperative Levosimendan Infusion in Patients With End-Stage Heart Failure Undergoing Left Ventricular Assist Device Implantation

Mahmoud Abdelshafy, Hagar Elsherbini, Ahmed Elkoumy, Andrew J. Simpkin, Hesham Elzomor, Kadir Caliskan*, Osama Soliman*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

6 Citations (Scopus)
26 Downloads (Pure)


Left ventricular assist device (LVAD) therapy has been instrumental in saving lives of patients with end-stage heart failure (HF). Recent generation devices have short-to-mid-term survival rates close to heart transplantation. Unfortunately, up to 1 in 4 patients develop a life-threatening right-sided HF (RHF) early post LVAD implantation, with high morbidity and mortality rate, necessitating prolonged ICU stay, prolonged inotropic support, and implantation of a right-ventricular assist device. Pre-operative optimization of HF therapy could help in prevention, and/or mitigation of RHF. Levosimendan (LEVO) is a non-conventional inotropic agent that works by amplifying calcium sensitivity of troponin C in cardiac myocytes, without increasing the intra-cellular calcium or exacerbating ischemia. LEVO acts as an inodilator, which reduces the cardiac pre-, and after-load. LEVO administration is associated with hemodynamic improvements. Despite decades long of the use of LVAD and more than two decades of the use of LEVO for HF, the literature on LEVO use in LVAD is very limited. In this paper, we sought to conduct a systematic review to synthesize evidence related to the use of LEVO for the mitigation and/or prevention of RHF in patients undergoing LVAD implantation.

Original languageEnglish
Article number888136
JournalFrontiers in Cardiovascular Medicine
Publication statusPublished - 28 Apr 2022

Bibliographical note

Funding Information:
MA, AE, HeE are funded by CORRIB Research Scholarship. OS is an Science Foundation of Ireland Funded Investigator (internal Grant numbers RSF1832 and RIB1792).

Publisher Copyright:
Copyright © 2022 Abdelshafy, Elsherbini, Elkoumy, Simpkin, Elzomor, Caliskan and Soliman.


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