Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: Protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)

  • Koen P. Rovers
  • , Checca Bakkers
  • , Geert A.A.M. Simkens
  • , Jacobus W.A. Burger
  • , Simon W. Nienhuijs
  • , Geert Jan M. Creemers
  • , Anna M.J. Thijs
  • , Alexandra R.M. Brandt-Kerkhof
  • , Eva V.E. Madsen
  • , Ninos Ayez
  • , Nadine L. De Boer
  • , Esther Van Meerten
  • , Jurriaan B. Tuynman
  • , Miranda Kusters
  • , Nina R. Sluiter
  • , Henk M.W. Verheul
  • , Hans J. Van Der Vliet
  • , Marinus J. Wiezer
  • , Djamila Boerma
  • , Emma C.E. Wassenaar
  • Maartje Los, Cornelis B. Hunting, Arend G.J. Aalbers, Niels F.M. Kok, Koert F.D. Kuhlmann, Henk Boot, Myriam Chalabi, Schelto Kruijff, Lukas B. Been, Robert J. Van Ginkel, Derk Jan A. De Groot, Rudolf S.N. Fehrmann, Johannes H.W. De Wilt, Andreas J.A. Bremers, Philip R. De Reuver, Sandra A. Radema, Karin H. Herbschleb, Wilhelmina M.U. Van Grevenstein, Arjen J. Witkamp, Miriam Koopman, Nadia Haj Mohammad, Eino B. Van Duyn, Walter J.B. Mastboom, Leonie J.M. Mekenkamp, Joost Nederend, Max J. Lahaye, Petur Snaebjornsson, Cornelis Verhoef, Hanneke W.M. Van Laarhoven, Aeilko H. Zwinderman, Jeanette M. Bouma, Onno Kranenburg, Iris Van 'T Erve, Remond J.A. Fijneman, Marcel G.W. Dijkgraaf, Patrick H.J. Hemmer, Cornelis J.A. Punt, Pieter J. Tanis, Ignace H.J.T. De Hingh*
*Corresponding author for this work

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