Personalized 3D printed scaffolds: The ethical aspects

Manon van Daal*, Anne Floor J. de Kanter, Annelien L. Bredenoord, Nienke de Graeff

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

2 Citations (Scopus)
32 Downloads (Pure)


Personalized 3D printed scaffolds are a new generation of implants for tissue engineering and regenerative medicine purposes. Scaffolds support cell growth, providing an artificial extracellular matrix for tissue repair and regeneration and can biodegrade once cells have assumed their physiological and structural roles. The ethical challenges and opportunities of these implants should be mapped in parallel with the life cycle of the scaffold to assist their development and implementation in a responsible, safe, and ethically sound manner. This article provides an overview of these relevant ethical aspects. We identified nine themes which were linked to three stages of the life cycle of the scaffold: the development process, clinical testing, and the implementation process. The described ethical issues are related to good research and clinical practices, such as privacy issues concerning digitalization, first-in-human trials, responsibility and commercialization. At the same time, this article also creates awareness for underexplored ethical issues, such as irreversibility, embodiment and the ontological status of these scaffolds. Moreover, it exemplifies how to include gender in the ethical assessment of new technologies. These issues are important for responsible development and implementation of personalized 3D printed scaffolds and in need of more attention within the additive manufacturing and tissue engineering field. Moreover, the insights of this review reveal unresolved qualitative empirical and normative questions that could further deepen the understanding and co-creation of the ethical implications of this new generation of implants.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalNew Biotechnology
Publication statusPublished - 25 Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors


Dive into the research topics of 'Personalized 3D printed scaffolds: The ethical aspects'. Together they form a unique fingerprint.

Cite this