Perspectives on Sex- and Gender-Specific Prediction of New-Onset Atrial Fibrillation by Leveraging Big Data

Sven Geurts, Zuolin Lu, Maryam Kavousi*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, has a large impact on quality of life and is associated with increased risk of hospitalization, morbidity, and mortality. Over the past two decades advances regarding the clinical epidemiology and management of AF have been established. Moreover, sex differences in the prevalence, incidence, prediction, pathophysiology, and prognosis of AF have been identified. Nevertheless, AF remains to be a complex and heterogeneous disorder and a comprehensive sex- and gender-specific approach to predict new-onset AF is lacking. The exponential growth in various sources of big data such as electrocardiograms, electronic health records, and wearable devices, carries the potential to improve AF risk prediction. Leveraging these big data sources by artificial intelligence (AI)-enabled approaches, in particular in a sex- and gender-specific manner, could lead to substantial advancements in AF prediction and ultimately prevention. We highlight the current status, premise, and potential of big data to improve sex- and gender-specific prediction of new-onset AF.

Original languageEnglish
Article number886469
JournalFrontiers in Cardiovascular Medicine
Publication statusPublished - 11 Jul 2022

Bibliographical note

Funding Information:
This study was further supported by the Senior Scientist Grant from Dutch Heart Foundation (03-004-2021-T050).

Publisher Copyright:
Copyright © 2022 Geurts, Lu and Kavousi.


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