@article{547d9aadac744c88b5e057d7d25ee744,
title = "Perspectives on the Risk-Stratified Treatment of Multiple Myeloma",
abstract = "The multiple myeloma treatment landscape has changed dramatically. This change, paralleled by an increase in scientific knowledge, has resulted in significant improvement in survival. However, heterogeneity remains in clinical outcomes, with a proportion of patients not benefiting from current approaches and continuing to have a poor prognosis. A significant proportion of the variability in outcome can be predicted on the basis of clinical and biochemical parameters and tumor-acquired genetic variants, allowing for risk stratification and a more personalized approach to therapy. This article discusses the principles that can enable the rational and effective development of therapeutic approaches for high-risk multiple myeloma.",
author = "Davies, {Faith E.} and Charlotte Pawlyn and Usmani, {Saad Z.} and San-Miguel, {Jesus F.} and Hermann Einsele and Boyle, {Eileen M.} and Jill Corre and Daniel Auclair and Cho, {Hearn Jay} and Sagar Lonial and Pieter Sonneveld and Stewart, {A. Keith} and Bergsagel, {P. Leif} and Kaiser, {Martin F.} and Katja Weisel and Keats, {Jonathan J.} and Mikhael, {Joseph R.} and Morgan, {Kathryn E.} and Ghobrial, {Irene M.} and Orlowski, {Robert Z.} and Landgren, {C. Ola} and Francesca Gay and Joseph Caers and Chng, {Wee Joo} and Ajai Chari and Walker, {Brian A.} and Kumar, {Shaji K.} and Costa, {Luciano J.} and Anderson, {Kenneth C.} and Morgan, {Gareth J.}",
note = "Publisher Copyright: {\textcopyright}2022 The Authors; Published by the American Association for Cancer Research.",
year = "2022",
month = jul,
day = "1",
doi = "10.1158/2643-3230.BCD-21-0205",
language = "English",
volume = "3",
pages = "273--284",
journal = "Blood cancer discovery",
issn = "2643-3230",
publisher = "NLM (Medline)",
number = "7",
}