Pharmacogenetics of tomorrow: the 1 + 1 = 3 principle

Jan Pander, Judith A M Wessels, Ron H J Mathijssen, Hans Gelderblom, Henk-Jan Guchelaar*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Disappointing results from replicating pharmacogenetic association studies have prompted the search for novel statistical techniques to analyze the data, while taking into account the biological complexity underlying drug response. Two of these techniques multifactor dimensionality reduction and classification and regression tree analysis will probably be applied in increasing numbers of future pharmacogenetic studies. In this article, we describe the concepts underlying both techniques and illustrate their application in a recent pharmacogenetic study.
Original languageEnglish
Pages (from-to)1011-1017
Number of pages7
JournalPharmacogenomics
Volume11
Issue number7
DOIs
Publication statusPublished - 6 Jul 2010

Research programs

  • EMC MM-03-86-08

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