Pharmacogenomics and therapeutics of hemoglobinopathies

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Abstract

Individual genetic constitution is an important cause of variations in the response and tolerance to drug treatment. Single nucleotide polymorphisms (SNPs) in genes located within as well as outside the human beta-globin cluster have recently been shown to be significantly associated with Hb F increase in relation to hydroxyurea (HU) treatment in hemoglobinopathies patients. This article provides an update and discusses future challenges on the application of pharmacogenetic testing and pharmacogenomics for hemoglobinopathies therapeutics in relation to the current pharmacological treatment modalities for those disorders.
Original languageUndefined/Unknown
Pages (from-to)229-236
Number of pages8
JournalHemoglobin
Volume32
Issue number1-2
DOIs
Publication statusPublished - 2008

Research programs

  • EMC MGC-02-13-02

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