Pharmacokinetic interaction between nortriptyline and terbinafine

P. Hugo M. Van der Kuy; Harrie A. van den Heuvel; Rob W. Kempen; Leo M.L. Vanmolkot

doi:10.1345/aph.1C083

Pharmacokinetic interaction between nortriptyline and terbinafine

P. Hugo M. Van der Kuy^*, Harrie A. van den Heuvel, Rob W. Kempen, Leo M.L. Vanmolkot

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

31 Downloads (Pure)

Abstract

OBJECTIVE: To clarify the mechanism of interaction between nortriptyline and terbinafine. CASE SUMMARY: Nortriptyline intoxication secondary to terbinafine treatment was observed in a woman with a major depressive disorder. This is the second report of this interaction. A rechallenge was performed during which serum concentrations were measured of nortriptyline and the 2 hydroxy metabolites. To document the case, genotyping of CYP2D6 was also performed. DISCUSSION: Metabolism by CYP2D6 is of major importance for the hydroxylation of nortriptyline, making it susceptible to competitive inhibition by terbinafine. CONCLUSIONS: The pharmacokinetic interaction between nortriptyline and terbinafine is probably due to inhibition of CYP2D6 of the nortriptyline metabolism by terbinafine. The interaction is not restricted to a subpopulation, but may occur even in persons without deviations in CYP2D6.

Original language	English
Pages (from-to)	1712-1714
Number of pages	3
Journal	Annals of Pharmacotherapy
Volume	36
Issue number	11
DOIs	https://doi.org/10.1345/aph.1C083
Publication status	Published - Nov 2002
Externally published	Yes

Access to Document

10.1345/aph.1C083

van-der-kuy-et-al-2002-pharmacokinetic-interaction-between-nortriptyline-and-terbinafineFinal published version, 177 KB

Cite this

@article{03379265d14841a4a23c84a3863218f4,

title = "Pharmacokinetic interaction between nortriptyline and terbinafine",

abstract = "OBJECTIVE: To clarify the mechanism of interaction between nortriptyline and terbinafine. CASE SUMMARY: Nortriptyline intoxication secondary to terbinafine treatment was observed in a woman with a major depressive disorder. This is the second report of this interaction. A rechallenge was performed during which serum concentrations were measured of nortriptyline and the 2 hydroxy metabolites. To document the case, genotyping of CYP2D6 was also performed. DISCUSSION: Metabolism by CYP2D6 is of major importance for the hydroxylation of nortriptyline, making it susceptible to competitive inhibition by terbinafine. CONCLUSIONS: The pharmacokinetic interaction between nortriptyline and terbinafine is probably due to inhibition of CYP2D6 of the nortriptyline metabolism by terbinafine. The interaction is not restricted to a subpopulation, but may occur even in persons without deviations in CYP2D6.",

author = "{Van der Kuy}, {P. Hugo M.} and {van den Heuvel}, {Harrie A.} and Kempen, {Rob W.} and Vanmolkot, {Leo M.L.}",

year = "2002",

month = nov,

doi = "10.1345/aph.1C083",

language = "English",

volume = "36",

pages = "1712--1714",

journal = "Annals of Pharmacotherapy",

issn = "1060-0280",

publisher = "SAGE Publications",

number = "11",

}

TY - JOUR

T1 - Pharmacokinetic interaction between nortriptyline and terbinafine

AU - Van der Kuy, P. Hugo M.

AU - van den Heuvel, Harrie A.

AU - Kempen, Rob W.

AU - Vanmolkot, Leo M.L.

PY - 2002/11

Y1 - 2002/11

N2 - OBJECTIVE: To clarify the mechanism of interaction between nortriptyline and terbinafine. CASE SUMMARY: Nortriptyline intoxication secondary to terbinafine treatment was observed in a woman with a major depressive disorder. This is the second report of this interaction. A rechallenge was performed during which serum concentrations were measured of nortriptyline and the 2 hydroxy metabolites. To document the case, genotyping of CYP2D6 was also performed. DISCUSSION: Metabolism by CYP2D6 is of major importance for the hydroxylation of nortriptyline, making it susceptible to competitive inhibition by terbinafine. CONCLUSIONS: The pharmacokinetic interaction between nortriptyline and terbinafine is probably due to inhibition of CYP2D6 of the nortriptyline metabolism by terbinafine. The interaction is not restricted to a subpopulation, but may occur even in persons without deviations in CYP2D6.

AB - OBJECTIVE: To clarify the mechanism of interaction between nortriptyline and terbinafine. CASE SUMMARY: Nortriptyline intoxication secondary to terbinafine treatment was observed in a woman with a major depressive disorder. This is the second report of this interaction. A rechallenge was performed during which serum concentrations were measured of nortriptyline and the 2 hydroxy metabolites. To document the case, genotyping of CYP2D6 was also performed. DISCUSSION: Metabolism by CYP2D6 is of major importance for the hydroxylation of nortriptyline, making it susceptible to competitive inhibition by terbinafine. CONCLUSIONS: The pharmacokinetic interaction between nortriptyline and terbinafine is probably due to inhibition of CYP2D6 of the nortriptyline metabolism by terbinafine. The interaction is not restricted to a subpopulation, but may occur even in persons without deviations in CYP2D6.

UR - http://www.scopus.com/inward/record.url?scp=0036841165&partnerID=8YFLogxK

U2 - 10.1345/aph.1C083

DO - 10.1345/aph.1C083

M3 - Article

C2 - 12398564

AN - SCOPUS:0036841165

SN - 1060-0280

VL - 36

SP - 1712

EP - 1714

JO - Annals of Pharmacotherapy

JF - Annals of Pharmacotherapy

IS - 11

ER -

Pharmacokinetic interaction between nortriptyline and terbinafine

Abstract

Access to Document

Other files and links

Fingerprint

Cite this