Pharmacological and Non-Pharmacological Interventions for Depression after Moderate-to-Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Lianne D. Peppel, Gerard M. Ribbers, Majanka H. Heijenbrok-Kal*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

The objective of this study was to systematically review the literature and perform a meta-analysis of randomized controlled trials (RCTs) on the effectiveness of pharmacological and non-pharmacological interventions for depression in patients with moderate-to-severe traumatic brain injury. Databases searched were: Embase, PubMed, PsycInfo, Cochrane Central, Web of Science, and Google Scholar. Depression score on a self-report questionnaire was the outcome measure. Outcomes were collected at baseline and at the first follow-up moment. Data extraction was executed independently by two researchers. Thirteen RCTs were identified: five pharmacological and eight non-pharmacological. Although not all individual studies had significant results, the overall standardized mean difference (SMD) was -0.395, p
Original languageEnglish
Pages (from-to)1587-1596
Number of pages10
JournalJournal of Neurotrauma
Volume37
Issue number14
Early online dateApr 2020
DOIs
Publication statusPublished - 22 Jun 2020

Bibliographical note

Funding Information
This study was partly funded by the Dutch Brain Foundation
(PS2014-06).

Research programs

  • EMC OR-01

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