TY - JOUR
T1 - Pharmacological and Non-Pharmacological Interventions for Depression after Moderate-to-Severe Traumatic Brain Injury
T2 - A Systematic Review and Meta-Analysis
AU - Peppel, Lianne D.
AU - Ribbers, Gerard M.
AU - Heijenbrok-Kal, Majanka H.
N1 - Funding Information
This study was partly funded by the Dutch Brain Foundation
(PS2014-06).
PY - 2020/6/22
Y1 - 2020/6/22
N2 - The objective of this study was to systematically review the literature and perform a meta-analysis of randomized controlled trials (RCTs) on the effectiveness of pharmacological and non-pharmacological interventions for depression in patients with moderate-to-severe traumatic brain injury. Databases searched were: Embase, PubMed, PsycInfo, Cochrane Central, Web of Science, and Google Scholar. Depression score on a self-report questionnaire was the outcome measure. Outcomes were collected at baseline and at the first follow-up moment. Data extraction was executed independently by two researchers. Thirteen RCTs were identified: five pharmacological and eight non-pharmacological. Although not all individual studies had significant results, the overall standardized mean difference (SMD) was -0.395, p
AB - The objective of this study was to systematically review the literature and perform a meta-analysis of randomized controlled trials (RCTs) on the effectiveness of pharmacological and non-pharmacological interventions for depression in patients with moderate-to-severe traumatic brain injury. Databases searched were: Embase, PubMed, PsycInfo, Cochrane Central, Web of Science, and Google Scholar. Depression score on a self-report questionnaire was the outcome measure. Outcomes were collected at baseline and at the first follow-up moment. Data extraction was executed independently by two researchers. Thirteen RCTs were identified: five pharmacological and eight non-pharmacological. Although not all individual studies had significant results, the overall standardized mean difference (SMD) was -0.395, p
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:000525543300001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1089/neu.2019.6735
DO - 10.1089/neu.2019.6735
M3 - Article
C2 - 32041474
SN - 0897-7151
VL - 37
SP - 1587
EP - 1596
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 14
ER -