Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer

Lia Zuylen; J Bridgewater; A Sparreboom; Ferry Eskens; Peter de Bruijn; I Sklenar; AST Planting; L Choi; D Bootle; C Mueller; JA Ledermann; Jaap Verweij

doi:10.1158/1078-0432.CCR-02-0995

Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer

Lia Zuylen, J Bridgewater, A Sparreboom, Ferry Eskens, Peter de Bruijn, I Sklenar, AST Planting, L Choi, D Bootle, C Mueller, JA Ledermann, Jaap Verweij

Medical Oncology

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

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Original language	Undefined/Unknown
Pages (from-to)	1949-1955
Number of pages	7
Journal	Clinical Cancer Research
Volume	10
DOIs	https://doi.org/10.1158/1078-0432.CCR-02-0995
Publication status	Published - 2004

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EMC MM-03-86-08

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10.1158/1078-0432.CCR-02-0995

15041711.pdfFinal published version, 91 KB

http://hdl.handle.net/1765/10327

Cite this

Zuylen, L., Bridgewater, J., Sparreboom, A., Eskens, F., de Bruijn, P., Sklenar, I., Planting, AST., Choi, L., Bootle, D., Mueller, C., Ledermann, JA., & Verweij, J. (2004). Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer. Clinical Cancer Research, 10, 1949-1955. https://doi.org/10.1158/1078-0432.CCR-02-0995

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title = "Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer",

author = "Lia Zuylen and J Bridgewater and A Sparreboom and Ferry Eskens and {de Bruijn}, Peter and I Sklenar and AST Planting and L Choi and D Bootle and C Mueller and JA Ledermann and Jaap Verweij",

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Zuylen, L, Bridgewater, J, Sparreboom, A, Eskens, F , de Bruijn, P, Sklenar, I, Planting, AST, Choi, L, Bootle, D, Mueller, C, Ledermann, JA & Verweij, J 2004, 'Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer', Clinical Cancer Research, vol. 10, pp. 1949-1955. https://doi.org/10.1158/1078-0432.CCR-02-0995

TY - JOUR

T1 - Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer

AU - Zuylen, Lia

AU - Bridgewater, J

AU - Sparreboom, A

AU - Eskens, Ferry

AU - de Bruijn, Peter

AU - Sklenar, I

AU - Planting, AST

AU - Choi, L

AU - Bootle, D

AU - Mueller, C

AU - Ledermann, JA

AU - Verweij, Jaap

PY - 2004

Y1 - 2004

U2 - 10.1158/1078-0432.CCR-02-0995

DO - 10.1158/1078-0432.CCR-02-0995

M3 - Article

SN - 1078-0432

VL - 10

SP - 1949

EP - 1955

JO - Clinical Cancer Research

JF - Clinical Cancer Research

ER -