Phthalate and bisphenol urinary concentrations, body fat neasures, and cardiovascular risk factors in Dutch school-age children

Carolina Costa Vicente Silva, Vincent Jaddoe, Chalana Sol, Hanan El Marroun, MP Martinez-Moral, K Kannan, L Trasande, S Santos

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
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Abstract

Objective: The purpose of this study was to investigate the associations of urinary phthalates and bisphenols at age 6 years old with body fat and cardiovascular risk factors at 6 and 10 years and with the change from 6 to 10 years. Methods: Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass, blood pressure, glucose, insulin, and lipids blood concentrations at 6 and 10 years were measured. Results: An interquartile range increase in di-n-octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11-1.87, and 1.43; 95% CI: 1.09-1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at 6 years, higher systolic blood pressure at 10 years, a decrease in high-density lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years (P < 0.05). Higher total bisphenols and bisphenol A concentrations were associated with a decrease in BMI from 6 to 10 years (P < 0.01). Conclusions: DNOP metabolites are associated with overweight and an adverse cardiovascular profile in childhood. Total bisphenols and bisphenol A are associated with a decrease in BMI from 6 to 10 years.

Original languageEnglish
Pages (from-to)409-417
Number of pages9
JournalObesity
Volume29
Issue number2
DOIs
Publication statusPublished - 24 Jan 2021

Bibliographical note

Funding Information:
The general design of the Generation R Study was made possible by financial support from the Erasmus MC, University Medical Center, Rotterdam, the Netherlands; the Organization for Health Research and Development (ZonMw); and the Ministry of Health, Welfare and Sport. This study was supported by the US National Institutes of Health (NIH) (grants RO1 ES022972 and RO1 ES029779). The content is solely the responsibility of the authors and does not represent the official views of NIH. VJ received an additional grant from the European Research Council (ERC Consolidator grant, ERC‐2014‐CoG‐64916). All funding sources had no involvement in study design, the collection, analysis, and interpretation of data, the writing of the report, and in the decision to submit the article for publication.

Publisher Copyright:
© 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

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