Physical activity and cognitive vitality: Insights from the Rotterdam Study and an intervention study in healthy older adults

Sara Galle

Physical activity and cognitive vitality: Insights from the Rotterdam Study and an intervention study in healthy older adults

Sara Galle

Epidemiology

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

Physical inactivity is considered a promising intervention target to delay or prevent the development of accelerated cognitive decline and dementia. The main objective of this thesis was to investigate causality in the relation between physical activity and cognitive vitality. In addition, the potential moderating role of genetic susceptibility to Alzheimer's disease, based on the APOE gene and the predicitve validity of neurotrophic factors IGF-I and BDNF is investigated.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	van Duijn, Cornelia, Supervisor Drent, Madeleine, Supervisor Deijen, JB, Co-supervisor, External person Milders, MV, Co-supervisor, External person
Award date	15 Mar 2023
Place of Publication	Rotterdam
Print ISBNs	9789464588705
Publication status	Published - 15 Mar 2023

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final dissertation Galle, SaraFinal published version, 2.82 MB

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title = "Physical activity and cognitive vitality: Insights from the Rotterdam Study and an intervention study in healthy older adults",

abstract = "Physical inactivity is considered a promising intervention target to delay or prevent the development of accelerated cognitive decline and dementia. The main objective of this thesis was to investigate causality in the relation between physical activity and cognitive vitality. In addition, the potential moderating role of genetic susceptibility to Alzheimer's disease, based on the APOE gene and the predicitve validity of neurotrophic factors IGF-I and BDNF is investigated.",

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T2 - Insights from the Rotterdam Study and an intervention study in healthy older adults

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N2 - Physical inactivity is considered a promising intervention target to delay or prevent the development of accelerated cognitive decline and dementia. The main objective of this thesis was to investigate causality in the relation between physical activity and cognitive vitality. In addition, the potential moderating role of genetic susceptibility to Alzheimer's disease, based on the APOE gene and the predicitve validity of neurotrophic factors IGF-I and BDNF is investigated.

AB - Physical inactivity is considered a promising intervention target to delay or prevent the development of accelerated cognitive decline and dementia. The main objective of this thesis was to investigate causality in the relation between physical activity and cognitive vitality. In addition, the potential moderating role of genetic susceptibility to Alzheimer's disease, based on the APOE gene and the predicitve validity of neurotrophic factors IGF-I and BDNF is investigated.

M3 - Doctoral Thesis

SN - 9789464588705

CY - Rotterdam

ER -

Physical activity and cognitive vitality: Insights from the Rotterdam Study and an intervention study in healthy older adults

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