Physical fitness and its association with fatigue in patients with low-grade glioma

Ellen M. P. van Coevorden-van Loon; Herwin H. L. D. Horemans; Majanka H. Heijenbrok-Kal; Rita J. G. van den Berg-Emons; Robert Rozenberg; Arnaud J. P. E. Vincent; Gerard M. Ribbers; Martin J. van den Bent

doi:10.1080/09638288.2022.2125084

Physical fitness and its association with fatigue in patients with low-grade glioma

Ellen M. P. van Coevorden-van Loon^*, Herwin H. L. D. Horemans, Majanka H. Heijenbrok-Kal, Rita J. G. van den Berg-Emons, Robert Rozenberg, Arnaud J. P. E. Vincent, Gerard M. Ribbers, Martin J. van den Bent

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose: To evaluate physical fitness and its association with fatigue in patients with low grade glioma (LGG). Methods: Cross-sectional study. Muscle strength was measured with a digital dynamometer, cardiorespiratory fitness (peak oxygen uptake (VO2peak), maximal workload (MWL)) by cardiopulmonary-exercise-testing, and fatigue by using the Multidimensional Fatigue Inventory. Results: Thirty patients were included, mean age of 44.1 (SD11.2) years, and 67% were men, 31.2 (SD18) months post-diagnosis. Muscle strength (p < 0.01), and cardiorespiratory fitness (VO _2peak, MWL) (p < 0.01) were significantly decreased compared to predicted values based on age and gender. Thirty percent of the patients experienced severe physical fatigue, and severe mental fatigue was reported in 57% of the patients. Cardiorespiratory fitness showed weak to moderate (r − 0.46 to r − 0.52) but significant (p < 0.01) correlations with physical fatigue, not with mental and general fatigue. Muscle strength was not associated with fatigue. A lower VO _2peak was independently associated with a higher level of physical fatigue, adjusted for Karnofsky Performance Status (R ² 0.40). Conclusions: Physical fitness (muscle strength, cardiorespiratory fitness) is reduced in patients with LLG, and a lower level of cardiorespiratory fitness (VO _2peak) is independently associated with a higher level of experienced physical fatigue. Trials to explore the benefit of exercise programs to improve cardiorespiratory fitness and, consequently, fatigue are warranted.Implications for rehabilitation Physical fitness (muscle strength and cardiorespiratory fitness) is reduced in patients with low-grade glioma. Patients with low-grade glioma should be screened for fatigue with the multidimensional fatigue inventory, to differentiate between mental and physical fatigue. Patients with low-grade glioma with severe physical fatigue should be screened for reduced physical fitness, especially cardiorespiratory fitness by objective cardiopulmonary-exercise-testing. Rehabilitation exercise programs to improve cardiorespiratory fitness and, consequently, (physical) fatigue could be warranted in patients with low-grade glioma.

Original language	English
Pages (from-to)	3323-3329
Number of pages	7
Journal	Disability and Rehabilitation
Volume	45
Issue number	20
Early online date	22 Sept 2022
DOIs	https://doi.org/10.1080/09638288.2022.2125084
Publication status	Published - 2023

Bibliographical note

Funding Information:
The author(s) reported there is no funding associated with the work featured in this article. The authors thank Emiel Sneekes for his contribution to the data collection.

Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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Physical fitness and its association with fatigue in patients with low-grade gliomaFinal published version, 1.65 MBLicence: CC BY-NC-ND

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van Coevorden-van Loon, E. M. P., Horemans, H. H. L. D., Heijenbrok-Kal, M. H., van den Berg-Emons, R. J. G., Rozenberg, R., Vincent, A. J. P. E., Ribbers, G. M., & van den Bent, M. J. (2023). Physical fitness and its association with fatigue in patients with low-grade glioma. Disability and Rehabilitation, 45(20), 3323-3329. https://doi.org/10.1080/09638288.2022.2125084

@article{cd362dd7da244c6d8174030f62f7a6af,

title = "Physical fitness and its association with fatigue in patients with low-grade glioma",

abstract = "Purpose: To evaluate physical fitness and its association with fatigue in patients with low grade glioma (LGG). Methods: Cross-sectional study. Muscle strength was measured with a digital dynamometer, cardiorespiratory fitness (peak oxygen uptake (VO2peak), maximal workload (MWL)) by cardiopulmonary-exercise-testing, and fatigue by using the Multidimensional Fatigue Inventory. Results: Thirty patients were included, mean age of 44.1 (SD11.2) years, and 67% were men, 31.2 (SD18) months post-diagnosis. Muscle strength (p < 0.01), and cardiorespiratory fitness (VO 2peak, MWL) (p < 0.01) were significantly decreased compared to predicted values based on age and gender. Thirty percent of the patients experienced severe physical fatigue, and severe mental fatigue was reported in 57% of the patients. Cardiorespiratory fitness showed weak to moderate (r − 0.46 to r − 0.52) but significant (p < 0.01) correlations with physical fatigue, not with mental and general fatigue. Muscle strength was not associated with fatigue. A lower VO 2peak was independently associated with a higher level of physical fatigue, adjusted for Karnofsky Performance Status (R 2 0.40). Conclusions: Physical fitness (muscle strength, cardiorespiratory fitness) is reduced in patients with LLG, and a lower level of cardiorespiratory fitness (VO 2peak) is independently associated with a higher level of experienced physical fatigue. Trials to explore the benefit of exercise programs to improve cardiorespiratory fitness and, consequently, fatigue are warranted.Implications for rehabilitation Physical fitness (muscle strength and cardiorespiratory fitness) is reduced in patients with low-grade glioma. Patients with low-grade glioma should be screened for fatigue with the multidimensional fatigue inventory, to differentiate between mental and physical fatigue. Patients with low-grade glioma with severe physical fatigue should be screened for reduced physical fitness, especially cardiorespiratory fitness by objective cardiopulmonary-exercise-testing. Rehabilitation exercise programs to improve cardiorespiratory fitness and, consequently, (physical) fatigue could be warranted in patients with low-grade glioma.",

author = "{van Coevorden-van Loon}, {Ellen M. P.} and Horemans, {Herwin H. L. D.} and Heijenbrok-Kal, {Majanka H.} and {van den Berg-Emons}, {Rita J. G.} and Robert Rozenberg and Vincent, {Arnaud J. P. E.} and Ribbers, {Gerard M.} and {van den Bent}, {Martin J.}",

note = "Funding Information: The author(s) reported there is no funding associated with the work featured in this article. The authors thank Emiel Sneekes for his contribution to the data collection. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2023",

doi = "10.1080/09638288.2022.2125084",

language = "English",

volume = "45",

pages = "3323--3329",

journal = "Disability and Rehabilitation",

issn = "0963-8288",

publisher = "Informa Healthcare",

number = "20",

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TY - JOUR

T1 - Physical fitness and its association with fatigue in patients with low-grade glioma

AU - van Coevorden-van Loon, Ellen M. P.

AU - Horemans, Herwin H. L. D.

AU - Heijenbrok-Kal, Majanka H.

AU - van den Berg-Emons, Rita J. G.

AU - Rozenberg, Robert

AU - Vincent, Arnaud J. P. E.

AU - Ribbers, Gerard M.

AU - van den Bent, Martin J.

N1 - Funding Information: The author(s) reported there is no funding associated with the work featured in this article. The authors thank Emiel Sneekes for his contribution to the data collection. Publisher Copyright: © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

PY - 2023

Y1 - 2023

N2 - Purpose: To evaluate physical fitness and its association with fatigue in patients with low grade glioma (LGG). Methods: Cross-sectional study. Muscle strength was measured with a digital dynamometer, cardiorespiratory fitness (peak oxygen uptake (VO2peak), maximal workload (MWL)) by cardiopulmonary-exercise-testing, and fatigue by using the Multidimensional Fatigue Inventory. Results: Thirty patients were included, mean age of 44.1 (SD11.2) years, and 67% were men, 31.2 (SD18) months post-diagnosis. Muscle strength (p < 0.01), and cardiorespiratory fitness (VO 2peak, MWL) (p < 0.01) were significantly decreased compared to predicted values based on age and gender. Thirty percent of the patients experienced severe physical fatigue, and severe mental fatigue was reported in 57% of the patients. Cardiorespiratory fitness showed weak to moderate (r − 0.46 to r − 0.52) but significant (p < 0.01) correlations with physical fatigue, not with mental and general fatigue. Muscle strength was not associated with fatigue. A lower VO 2peak was independently associated with a higher level of physical fatigue, adjusted for Karnofsky Performance Status (R 2 0.40). Conclusions: Physical fitness (muscle strength, cardiorespiratory fitness) is reduced in patients with LLG, and a lower level of cardiorespiratory fitness (VO 2peak) is independently associated with a higher level of experienced physical fatigue. Trials to explore the benefit of exercise programs to improve cardiorespiratory fitness and, consequently, fatigue are warranted.Implications for rehabilitation Physical fitness (muscle strength and cardiorespiratory fitness) is reduced in patients with low-grade glioma. Patients with low-grade glioma should be screened for fatigue with the multidimensional fatigue inventory, to differentiate between mental and physical fatigue. Patients with low-grade glioma with severe physical fatigue should be screened for reduced physical fitness, especially cardiorespiratory fitness by objective cardiopulmonary-exercise-testing. Rehabilitation exercise programs to improve cardiorespiratory fitness and, consequently, (physical) fatigue could be warranted in patients with low-grade glioma.

AB - Purpose: To evaluate physical fitness and its association with fatigue in patients with low grade glioma (LGG). Methods: Cross-sectional study. Muscle strength was measured with a digital dynamometer, cardiorespiratory fitness (peak oxygen uptake (VO2peak), maximal workload (MWL)) by cardiopulmonary-exercise-testing, and fatigue by using the Multidimensional Fatigue Inventory. Results: Thirty patients were included, mean age of 44.1 (SD11.2) years, and 67% were men, 31.2 (SD18) months post-diagnosis. Muscle strength (p < 0.01), and cardiorespiratory fitness (VO 2peak, MWL) (p < 0.01) were significantly decreased compared to predicted values based on age and gender. Thirty percent of the patients experienced severe physical fatigue, and severe mental fatigue was reported in 57% of the patients. Cardiorespiratory fitness showed weak to moderate (r − 0.46 to r − 0.52) but significant (p < 0.01) correlations with physical fatigue, not with mental and general fatigue. Muscle strength was not associated with fatigue. A lower VO 2peak was independently associated with a higher level of physical fatigue, adjusted for Karnofsky Performance Status (R 2 0.40). Conclusions: Physical fitness (muscle strength, cardiorespiratory fitness) is reduced in patients with LLG, and a lower level of cardiorespiratory fitness (VO 2peak) is independently associated with a higher level of experienced physical fatigue. Trials to explore the benefit of exercise programs to improve cardiorespiratory fitness and, consequently, fatigue are warranted.Implications for rehabilitation Physical fitness (muscle strength and cardiorespiratory fitness) is reduced in patients with low-grade glioma. Patients with low-grade glioma should be screened for fatigue with the multidimensional fatigue inventory, to differentiate between mental and physical fatigue. Patients with low-grade glioma with severe physical fatigue should be screened for reduced physical fitness, especially cardiorespiratory fitness by objective cardiopulmonary-exercise-testing. Rehabilitation exercise programs to improve cardiorespiratory fitness and, consequently, (physical) fatigue could be warranted in patients with low-grade glioma.

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DO - 10.1080/09638288.2022.2125084

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Physical fitness and its association with fatigue in patients with low-grade glioma

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