Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population

Jolien J. M. Freriksen*, Joyce E. M. van der Heijden, Marika A. de Hoop-Sommen, Rick Greupink, Saskia N. de Wildt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
16 Downloads (Pure)

Abstract

Physiologically based pharmacokinetic (PBPK) modeling can be an attractive tool to increase the evidence base of pediatric drug dosing recommendations by making optimal use of existing pharmacokinetic (PK) data. A pragmatic approach of combining available compound models with a virtual pediatric physiology model can be a rational solution to predict PK and hence support dosing guidelines for children in real-life clinical care, when it can also be employed by individuals with little experience in PBPK modeling. This comes within reach as user-friendly PBPK modeling platforms exist and, for many drugs and populations, models are ready for use. We have identified a list of drugs that can serve as a starting point for pragmatic PBPK modeling to address current clinical dosing needs.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalPaediatric Drugs
Volume25
Issue number1
Early online date6 Oct 2022
DOIs
Publication statusPublished - Jan 2023

Bibliographical note

Funding Information:
This publication is based on research funded by the Bill & Melinda Gates Foundation (Grant number: INV-001822). The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation.

Publisher Copyright:
© 2022, The Author(s).

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