Plasminmedieret aktivering af koagulationssystemet. En undersøgelse af patienter med akut iskoemisk hjertesygdom behandlet med rekombinant voevsplasminogenaktivator.

Translated title of the contribution: Plasmin-mediated activation of the coagulation system. : A study of patients with acute ischemic heart disease treated with recombinant tissue-plasminogen activator

J. B. Gram*, S. Munkvad, F. W. Leebeek, C. Kluft, J. Jespersen

*Corresponding author for this work

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Abstract

We have studied the response of haemostatic reaction products in peripheral blood of patients with acute ischaemic heart disease receiving combined recombinant tissue type plasminogen activator/heparin therapy. We have found evidence that formation of excessive amounts of plasmin in vivo in relation to such therapy significantly enhances the degradation of fibrin, and of fibrinogen as well as the formation of thrombin. We conclude that excessive plasmin formation by thrombolytic therapy causes systemic effects including activation of coagulation.

Translated title of the contributionPlasmin-mediated activation of the coagulation system. : A study of patients with acute ischemic heart disease treated with recombinant tissue-plasminogen activator
Original languageDanish
Pages (from-to)2746-2748, 2751-2752
Number of pages5
JournalUgeskrift for Laeger
Volume156
Issue number18
Publication statusPublished - 2 May 1994

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