Plasticity of visual evoked potentials in patients with neurofibromatosis type 1

J. Castricum, J. H.M. Tulen, A. M. Heuvelmans, G. Geleijnse, D. C.G. Straver, W. Taal, S. A. Kushner, Y. Elgersma*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objective: The inability to properly process visual information has been frequently associated with neurofibromatosis type 1 (NF1). Based on animal studies, the cause of cognitive disabilities in NF1 is hypothesized to arise from decreased synaptic plasticity. Visual cortical plasticity in humans can be investigated by studying visual evoked potentials (VEPs) in response to visual stimulation. Methods: VEP plasticity was assessed by measuring the increase of the peak amplitudes C1, P1, and N1 induced by 10-min modulation of checkerboard reversals in 22 adult NF1 patients and 30 controls. VEP signals were recorded pre-modulation, during modulation, and at 2, 7, 12, 17, 22, 27 min post-modulation. Results: The P1 amplitude increased significantly comparing post-modulation to pre-modulation in the control group. This potentiation was not observed in the NF1 group. Conclusions: Visual cortical plasticity could be measured using VEPs in response to visual stimulation in the control group. Individuals with NF1 may have reduced visual cortical plasticity, as indicated by their non-potentiated response to VEP induction. These findings should be interpreted with caution due to high inter-subject variability. Significance: The present study contributes to an improved assessment of the feasibility for using neurophysiological outcome measures in intervention studies of cognitive deficits among patients with NF1.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
JournalClinical Neurophysiology
Volume142
DOIs
Publication statusPublished - Oct 2022

Bibliographical note

Funding Information:
This work was supported by resources of the Department of Neuroscience, the Department of Clinical Genetics, the Department of Clinical Neurophysiology, and the Department of Psychiatry of the Erasmus Medical Center , Rotterdam, The Netherlands.

Publisher Copyright: © 2022 International Federation of Clinical Neurophysiology

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