Polycystic ovary syndrome: A brain disorder characterized by eating problems originating during puberty and adolescence

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
3 Downloads (Pure)

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine condition associated with reproductive and psychiatric disorders, and with obesity. Eating disorders, such as bulimia and recurrent dieting, are also linked to PCOS. They can lead to the epigenetic dysregulation of the hypothalamic–pituitary–gonadal (HPG) axis, thereby impacting on ovarian folliculogenesis. We postulate that PCOS is induced by psychological distress and episodes of overeating and/or dieting during puberty and adolescence, when body dissatisfaction and emotional distress are often present. We propose that upregulated activation of the central HPG axis during this period can be epigenetically altered by psychological stressors and by bulimia/recurrent dieting, which are common during adolescence and which can lead to PCOS. This hypothesis is based on events that occur during a largely neglected stage of female reproductive development. To date, most research into the origins of PCOS has focused on the prenatal induction of this disorder, particularly in utero androgenization and the role of anti-Müllerian hormone. Establishing causality in our peripubertal model requires prospective cohort studies from infancy. Mechanistic studies should consider the role of the gut microbiota in addition to the epigenetic regulation of (neuro) hormones. Finally, clinicians should consider the importance of underlying chronic psychological distress and eating disorders in PCOS.

Original languageEnglish
Article number8211
Pages (from-to)1-20
Number of pages20
JournalInternational Journal of Molecular Sciences
Volume21
Issue number21
Early online date3 Nov 2020
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
Funding: This work was funded by the Department of Obstetrics and Gynaecology of the Erasmus MC, University Medical Centre, Rotterdam, The Netherlands, and no external funding was either sought or obtained for this study. P.W.J. received support from ZonMW (Mental Health Care Research Program, Fellowship 636320005). K.D.S. was in receipt of funding from the Biotechnology and Biological Sciences Research Council, UK (BB/R007985/1) and the National Institute of Environmental Health Sciences, USA (1R01ES030374-01A1).

Funding Information:
Conflicts of Interest: J.S.E.L. has received fees or grant support in the most recent 5-year period from the following organizations (in alphabetical order): AnshLabs, Webster, TX, USA, the Dutch Heart Foundation, Utrecht NL, Dutch Medical Research Council (ZonMW), Amsterdam, NL, Astellas, Tokyo, Japan, Ferring, Hoofddorp, NL, Roche Diagnostics, Hochkreutz, Switzerland, and Titus Healthcare, Hoofddorp, NL. He also has received personal fees from AnshLabs, Webster, TX, USA, Ferring, Hoofddorp, NL and Titus Health Care, Hoofddorp, NL. The other authors declare no conflicts of interest.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Fingerprint

Dive into the research topics of 'Polycystic ovary syndrome: A brain disorder characterized by eating problems originating during puberty and adolescence'. Together they form a unique fingerprint.

Cite this