TY - JOUR
T1 - Polygenic risk scores for melanoma
T2 - a stepwise process towards clinical implementation
AU - Wakkee, Marlies
PY - 2022/5
Y1 - 2022/5
N2 - Early detection of melanoma or, even better, preventing mela-noma by educating and stimulating sun-protective behaviour,are still essential steps to reducing its global burden. However,evidence is insufficient to demonstrate the benefit of popula-tion-based screening by total body skin examination.1Poten-tially, focusing the screening on high-risk individuals may becost effective. Clinical implementation of polygenic risk scores(PRSs) is increasingly mentioned to facilitate this identificationof high-risk individuals (i.e. genetic risk stratification). [...]
AB - Early detection of melanoma or, even better, preventing mela-noma by educating and stimulating sun-protective behaviour,are still essential steps to reducing its global burden. However,evidence is insufficient to demonstrate the benefit of popula-tion-based screening by total body skin examination.1Poten-tially, focusing the screening on high-risk individuals may becost effective. Clinical implementation of polygenic risk scores(PRSs) is increasingly mentioned to facilitate this identificationof high-risk individuals (i.e. genetic risk stratification). [...]
UR - http://www.scopus.com/inward/record.url?scp=85129207585&partnerID=8YFLogxK
U2 - 10.1111/bjd.21296
DO - 10.1111/bjd.21296
M3 - Comment/Letter to the editor
C2 - 35501941
AN - SCOPUS:85129207585
SN - 0007-0963
VL - 186
SP - 768
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 5
ER -