Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

RA Power; S Steinberg; G Bjornsdottir; Niels Rietveld; A Abdellaoui; MM Nivard; M Johannesson; TE Galesloot; JJ (Jouke Jan) Hottenga; G Willemsen; D Cesarini; DJ Benjamin; PKE Magnusson; F Ullen; Henning Tiemeier; Bert Hofman; FJA van Rooij; GB Walters; E Sigurdsson; TE Thorgeirsson; A Ingason; A Helgason; A Kong; LA Kiemeney; P Koellinger; DI Boomsma; D Gudbjartsson; H Stefansson; K Stefansson

doi:10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

RA Power
, S Steinberg
, G Bjornsdottir
, Niels Rietveld
, A Abdellaoui
, MM Nivard
, M Johannesson
, TE Galesloot
, JJ (Jouke Jan) Hottenga
, G Willemsen
, D Cesarini
, DJ Benjamin
, PKE Magnusson
, F Ullen
, Henning Tiemeier
, Bert Hofman
, FJA van Rooij
, GB Walters
, E Sigurdsson
, TE Thorgeirsson

A Ingason, A Helgason, A Kong, LA Kiemeney, P Koellinger, DI Boomsma, D Gudbjartsson, H Stefansson, K Stefansson

Research output: Contribution to journal › Article › Academic › peer-review

308 Citations (Scopus)

Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4040
Publication status	Published - 2015

Research programs

EMC NIHES-01-64-01
EMC NIHES-04-55-01

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10.1038/nn.4040

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Power, RA., Steinberg, S., Bjornsdottir, G., Rietveld, N., Abdellaoui, A., Nivard, MM., Johannesson, M., Galesloot, TE., Hottenga, JJ., Willemsen, G., Cesarini, D., Benjamin, DJ., Magnusson, PKE., Ullen, F., Tiemeier, H., Hofman, B., van Rooij, FJA., Walters, GB., Sigurdsson, E., ... Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953-955. https://doi.org/10.1038/nn.4040

@article{9c5f3093ec044da489405e1266ec68da,

title = "Polygenic risk scores for schizophrenia and bipolar disorder predict creativity",

abstract = "We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.",

author = "RA Power and S Steinberg and G Bjornsdottir and Niels Rietveld and A Abdellaoui and MM Nivard and M Johannesson and TE Galesloot and Hottenga, \{JJ (Jouke Jan)\} and G Willemsen and D Cesarini and DJ Benjamin and PKE Magnusson and F Ullen and Henning Tiemeier and Bert Hofman and \{van Rooij\}, FJA and GB Walters and E Sigurdsson and TE Thorgeirsson and A Ingason and A Helgason and A Kong and LA Kiemeney and P Koellinger and DI Boomsma and D Gudbjartsson and H Stefansson and K Stefansson",

year = "2015",

doi = "10.1038/nn.4040",

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Power, RA, Steinberg, S, Bjornsdottir, G, Rietveld, N, Abdellaoui, A, Nivard, MM, Johannesson, M, Galesloot, TE, Hottenga, JJ, Willemsen, G, Cesarini, D, Benjamin, DJ, Magnusson, PKE, Ullen, F, Tiemeier, H , Hofman, B , van Rooij, FJA, Walters, GB, Sigurdsson, E, Thorgeirsson, TE, Ingason, A, Helgason, A, Kong, A, Kiemeney, LA, Koellinger, P, Boomsma, DI, Gudbjartsson, D, Stefansson, H & Stefansson, K 2015, 'Polygenic risk scores for schizophrenia and bipolar disorder predict creativity', Nature Neuroscience, vol. 18, no. 7, pp. 953-955. https://doi.org/10.1038/nn.4040

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T1 - Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

AU - Power, RA

AU - Steinberg, S

AU - Bjornsdottir, G

AU - Rietveld, Niels

AU - Abdellaoui, A

AU - Nivard, MM

AU - Johannesson, M

AU - Galesloot, TE

AU - Hottenga, JJ (Jouke Jan)

AU - Willemsen, G

AU - Cesarini, D

AU - Benjamin, DJ

AU - Magnusson, PKE

AU - Ullen, F

AU - Tiemeier, Henning

AU - Hofman, Bert

AU - van Rooij, FJA

AU - Walters, GB

AU - Sigurdsson, E

AU - Thorgeirsson, TE

AU - Ingason, A

AU - Helgason, A

AU - Kong, A

AU - Kiemeney, LA

AU - Koellinger, P

AU - Boomsma, DI

AU - Gudbjartsson, D

AU - Stefansson, H

AU - Stefansson, K

PY - 2015

Y1 - 2015

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AB - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

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DO - 10.1038/nn.4040

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VL - 18

SP - 953

EP - 955

JO - Nature Neuroscience

JF - Nature Neuroscience

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Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Abstract

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