Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice

Irene O.C.M. Vroegrijk, Janna A. van Diepen, Sjoerd van den Berg, Irene Westbroek, Hiskias Keizer, Luisa Gambelli, Raquel Hontecillas, Josep Bassaganya-Riera, Gerben C.M. Zondag, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

147 Citations (Scopus)

Abstract

Background: Pomegranate seed oil has been shown to protect against diet induced obesity and insulin resistance. Objective: To characterize the metabolic effects of punicic acid on high fat diet induced obesity and insulin resistance. Design: High-fat diet or high-fat diet with 1% Pomegranate seed oil (PUA) was fed for 12. weeks to induce obesity and insulin resistance. We assessed body weight and composition (pSABRE DEXA-scan), energy expenditure (Columbus Instruments) and insulin sensitivity at the end of the 12. weeks. Results: PSO intake resulted in a lower body weight, 30.5 ± 2.9 vs 33.8 ± 3.2. g PSO vs HFD respectively, p=0.02, without affecting food intake or energy expenditure. The lower body weight was fully explained by a decreased body fat mass, 3.3 ± 2.3 vs 6.7 ± 2.7. g for PSO and HFD fed mice, respectively, p=0.02. Insulin clamps showed that PSO did not affect liver insulin sensitivity but clearly improved peripheral insulin sensitivity, 164 ± 52% vs 92 ± 24% for PSO and HFD fed mice respectively, p=0.01. Conclusions: We conclude that dietary PSO ameliorates high-fat diet induced obesity and insulin resistance in mice, independent of changes in food intake or energy expenditure.

Original languageEnglish
Pages (from-to)1426-1430
Number of pages5
JournalFood and Chemical Toxicology
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Bibliographical note

Funding Information:
This work was performed in the framework of the Leiden Center for Cardiovascular Research LUMC-TNO and supported by grants from the Netherlands Organization for Scientific Research ( NWO Zon-MW; 917.76.301 to Peter J. Voshol) and the Dutch Diabetes Research Foundation ( 2005.01.003 to Peter J. Voshol), SenterNovem Grant IS055036 , the Centre for Medical Systems Biology (CMSB) in the framework of the Netherlands Genomics Initiative (NGI) (Project 115) , Top Institute Pharma (Project T2-105) and the Nutrigenomics Consortium, the seventh framework program of the EU-funded ‘‘LipidomicNet’’ (Proposal number 202272 ).

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