Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

Janko van Beek; Eeva Sajanti; Otto Helve; Jukka Ollgren; Mikko J. Virtanen; Harri Rissanen; Outi Lyytikäinen; Jukka Hytönen; Jussi Sane

doi:10.1016/j.ttbdis.2017.10.018

Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

Janko van Beek^*, Eeva Sajanti, Otto Helve, Jukka Ollgren, Mikko J. Virtanen, Harri Rissanen, Outi Lyytikäinen, Jukka Hytönen, Jussi Sane

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

Lyme borreliosis (LB) is caused by Borrelia burgdorferi sensu lato (Bb-sl) and is the most common vector-borne disease in Europe. The objectives of this study were to determine the Bb-sl seroprevalence among the general Finnish adult population and to identify risk factors associated with Bb-sl-seropositive status. Two thousand sera from a nationwide health survey from 2011 were tested by whole-cell sonicate IgG ELISA, C6 peptide ELISA, and recomBead IgG 2.0 and test results were linked to a general health questionnaire. A multivariable logistic regression model was used to identify risk factors. The median age of the study population was 56 years (range 29–97) and the Bb-sl weighted seroprevalence was 3.9% (95% confidence interval (CI) 3.03–5.08). The weighted seroprevalence was significantly higher among males than females (adjusted odds ratio 1.91, 95%CI 1.21–3.04). The seroprevalence was highest in Southern, Central, and Eastern regions. The first Bb-sl seroprevalence study in Finland showed a seroprevalence of 3.9% (regional range 0.87%–6.12%). The results of this study can be used, together with previous data on LB incidence and spatial tick distribution, to target public health communication about preventive measures.

Original language	English
Pages (from-to)	275-280
Number of pages	6
Journal	Ticks and Tick-borne Diseases
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.ttbdis.2017.10.018
Publication status	Published - Feb 2018
Externally published	Yes

Bibliographical note

Funding Information:
The study was financially supported by the Academy of Finland , a grant from Turku University Hospital (Diagnostics and Related Services), Doctoral Programme in Clinical Research of the University of Turku Graduate School.

Publisher Copyright:
© 2017 Elsevier GmbH

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10.1016/j.ttbdis.2017.10.018

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title = "Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland",

abstract = "Lyme borreliosis (LB) is caused by Borrelia burgdorferi sensu lato (Bb-sl) and is the most common vector-borne disease in Europe. The objectives of this study were to determine the Bb-sl seroprevalence among the general Finnish adult population and to identify risk factors associated with Bb-sl-seropositive status. Two thousand sera from a nationwide health survey from 2011 were tested by whole-cell sonicate IgG ELISA, C6 peptide ELISA, and recomBead IgG 2.0 and test results were linked to a general health questionnaire. A multivariable logistic regression model was used to identify risk factors. The median age of the study population was 56 years (range 29–97) and the Bb-sl weighted seroprevalence was 3.9\% (95\% confidence interval (CI) 3.03–5.08). The weighted seroprevalence was significantly higher among males than females (adjusted odds ratio 1.91, 95\%CI 1.21–3.04). The seroprevalence was highest in Southern, Central, and Eastern regions. The first Bb-sl seroprevalence study in Finland showed a seroprevalence of 3.9\% (regional range 0.87\%–6.12\%). The results of this study can be used, together with previous data on LB incidence and spatial tick distribution, to target public health communication about preventive measures.",

author = "\{van Beek\}, Janko and Eeva Sajanti and Otto Helve and Jukka Ollgren and Virtanen, \{Mikko J.\} and Harri Rissanen and Outi Lyytik{\"a}inen and Jukka Hyt{\"o}nen and Jussi Sane",

note = "Funding Information: The study was financially supported by the Academy of Finland , a grant from Turku University Hospital (Diagnostics and Related Services), Doctoral Programme in Clinical Research of the University of Turku Graduate School. Publisher Copyright: {\textcopyright} 2017 Elsevier GmbH",

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doi = "10.1016/j.ttbdis.2017.10.018",

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T1 - Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

AU - van Beek, Janko

AU - Sajanti, Eeva

AU - Helve, Otto

AU - Ollgren, Jukka

AU - Virtanen, Mikko J.

AU - Rissanen, Harri

AU - Lyytikäinen, Outi

AU - Hytönen, Jukka

AU - Sane, Jussi

N1 - Funding Information: The study was financially supported by the Academy of Finland , a grant from Turku University Hospital (Diagnostics and Related Services), Doctoral Programme in Clinical Research of the University of Turku Graduate School. Publisher Copyright: © 2017 Elsevier GmbH

PY - 2018/2

Y1 - 2018/2

N2 - Lyme borreliosis (LB) is caused by Borrelia burgdorferi sensu lato (Bb-sl) and is the most common vector-borne disease in Europe. The objectives of this study were to determine the Bb-sl seroprevalence among the general Finnish adult population and to identify risk factors associated with Bb-sl-seropositive status. Two thousand sera from a nationwide health survey from 2011 were tested by whole-cell sonicate IgG ELISA, C6 peptide ELISA, and recomBead IgG 2.0 and test results were linked to a general health questionnaire. A multivariable logistic regression model was used to identify risk factors. The median age of the study population was 56 years (range 29–97) and the Bb-sl weighted seroprevalence was 3.9% (95% confidence interval (CI) 3.03–5.08). The weighted seroprevalence was significantly higher among males than females (adjusted odds ratio 1.91, 95%CI 1.21–3.04). The seroprevalence was highest in Southern, Central, and Eastern regions. The first Bb-sl seroprevalence study in Finland showed a seroprevalence of 3.9% (regional range 0.87%–6.12%). The results of this study can be used, together with previous data on LB incidence and spatial tick distribution, to target public health communication about preventive measures.

AB - Lyme borreliosis (LB) is caused by Borrelia burgdorferi sensu lato (Bb-sl) and is the most common vector-borne disease in Europe. The objectives of this study were to determine the Bb-sl seroprevalence among the general Finnish adult population and to identify risk factors associated with Bb-sl-seropositive status. Two thousand sera from a nationwide health survey from 2011 were tested by whole-cell sonicate IgG ELISA, C6 peptide ELISA, and recomBead IgG 2.0 and test results were linked to a general health questionnaire. A multivariable logistic regression model was used to identify risk factors. The median age of the study population was 56 years (range 29–97) and the Bb-sl weighted seroprevalence was 3.9% (95% confidence interval (CI) 3.03–5.08). The weighted seroprevalence was significantly higher among males than females (adjusted odds ratio 1.91, 95%CI 1.21–3.04). The seroprevalence was highest in Southern, Central, and Eastern regions. The first Bb-sl seroprevalence study in Finland showed a seroprevalence of 3.9% (regional range 0.87%–6.12%). The results of this study can be used, together with previous data on LB incidence and spatial tick distribution, to target public health communication about preventive measures.

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SN - 1877-959X

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JO - Ticks and Tick-borne Diseases

JF - Ticks and Tick-borne Diseases

IS - 2

ER -

Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

Abstract

Bibliographical note

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