TY - JOUR
T1 - Population-based incidence rates of 15 neuromuscular disorders
T2 - a nationwide capture-recapture study in the Netherlands
AU - Deenen, Johanna C.W.
AU - Horlings, Corinne G.C.
AU - Voermans, Nicol C.
AU - van Doorn, Pieter A.
AU - Faber, Catharina G.
AU - van der Kooi, Anneke J.
AU - Kuks, Jan B.M.
AU - Notermans, Nicolette C.
AU - Visser, Leo H.
AU - Broekgaarden, Ria H.A.
AU - Horemans, Anja M.C.
AU - Verschuuren, Jan J.G.M.
AU - Verbeek, André L.M.
AU - van Engelen, Baziel G.M.
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/9
Y1 - 2024/9
N2 - Most neuromuscular disorders are rare, but as a group they are not. Nevertheless, epidemiological data of specific neuromuscular disorders are scarce, especially on the incidence. We applied a capture-recapture approach to a nationwide hospital-based dataset and a patients association-based dataset to estimate the annual incidence rates for fifteen neuromuscular disorders in the Netherlands. The annual incidence rates per 100,000 population varied from 0.03/100,000 (95% CI 0.00 ‒ 0.06) for glycogenosis type 5 to 0.9/100,000 (95% confidence interval 0.7 ‒ 1.0) for myotonic dystrophy type 1. The summed annual incidence rate of these disorders was 4.1 per 100,000 per population. Nine of the provided incidence rates were previously unavailable, three rates were similar to the rates in the literature, and three rates were generally higher compared to previous findings but with overlapping confidence intervals. This study provides nationwide incidence rates for fifteen neuromuscular disorders predominantly diagnosed in adult life, nine which were previously unavailable. The capture-recapture approach provided estimates of the total number of individuals with neuromuscular disorders. To complete the gaps in the knowledge of disease frequencies, there is a need for estimates from an automated, obligatory data collection system of diagnosed and newly diagnosed patients with neuromuscular disorders.
AB - Most neuromuscular disorders are rare, but as a group they are not. Nevertheless, epidemiological data of specific neuromuscular disorders are scarce, especially on the incidence. We applied a capture-recapture approach to a nationwide hospital-based dataset and a patients association-based dataset to estimate the annual incidence rates for fifteen neuromuscular disorders in the Netherlands. The annual incidence rates per 100,000 population varied from 0.03/100,000 (95% CI 0.00 ‒ 0.06) for glycogenosis type 5 to 0.9/100,000 (95% confidence interval 0.7 ‒ 1.0) for myotonic dystrophy type 1. The summed annual incidence rate of these disorders was 4.1 per 100,000 per population. Nine of the provided incidence rates were previously unavailable, three rates were similar to the rates in the literature, and three rates were generally higher compared to previous findings but with overlapping confidence intervals. This study provides nationwide incidence rates for fifteen neuromuscular disorders predominantly diagnosed in adult life, nine which were previously unavailable. The capture-recapture approach provided estimates of the total number of individuals with neuromuscular disorders. To complete the gaps in the knowledge of disease frequencies, there is a need for estimates from an automated, obligatory data collection system of diagnosed and newly diagnosed patients with neuromuscular disorders.
UR - http://www.scopus.com/inward/record.url?scp=85200641514&partnerID=8YFLogxK
U2 - 10.1016/j.nmd.2024.07.006
DO - 10.1016/j.nmd.2024.07.006
M3 - Article
C2 - 39116821
AN - SCOPUS:85200641514
SN - 0960-8966
VL - 42
SP - 27
EP - 35
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
ER -