Population-Level Antibody Estimates to Novel Influenza A/H7N9

MF Boni; NVV Chau; N Dong; S Todd; NTD Nhat; EI Bruin; J (Janko) van Beek; NT Hien; CP Simmons; J Farrar; Marion Koopmans

doi:10.1093/infdis/jit224

Population-Level Antibody Estimates to Novel Influenza A/H7N9

MF Boni, NVV Chau, N Dong, S Todd, NTD Nhat, EI Bruin, J (Janko) van Beek, NT Hien, CP Simmons, J Farrar, Marion Koopmans

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

Original language	Undefined/Unknown
Pages (from-to)	554-558
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	208
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jit224
Publication status	Published - 2013

Research programs

EMC MM-04-27-01

Access to Document

10.1093/infdis/jit224

http://hdl.handle.net/1765/60824

Cite this

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title = "Population-Level Antibody Estimates to Novel Influenza A/H7N9",

abstract = "There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.",

author = "MF Boni and NVV Chau and N Dong and S Todd and NTD Nhat and EI Bruin and {van Beek}, {J (Janko)} and NT Hien and CP Simmons and J Farrar and Marion Koopmans",

year = "2013",

doi = "10.1093/infdis/jit224",

language = "Undefined/Unknown",

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T1 - Population-Level Antibody Estimates to Novel Influenza A/H7N9

AU - Boni, MF

AU - Chau, NVV

AU - Dong, N

AU - Todd, S

AU - Nhat, NTD

AU - Bruin, EI

AU - van Beek, J (Janko)

AU - Hien, NT

AU - Simmons, CP

AU - Farrar, J

AU - Koopmans, Marion

PY - 2013

Y1 - 2013

N2 - There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

AB - There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

U2 - 10.1093/infdis/jit224

DO - 10.1093/infdis/jit224

M3 - Article

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SN - 0022-1899

VL - 208

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EP - 558

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -