Posaconazole Prophylaxis in Experimental Azole-Resistant Invasive Pulmonary Aspergillosis

Seyed Seyed Mousavi Tasieh; Johan Mouton; WJG Melchers; PE Verweij

doi:10.1128/AAC.03850-14

Posaconazole Prophylaxis in Experimental Azole-Resistant Invasive Pulmonary Aspergillosis

Seyed Seyed Mousavi Tasieh
, Johan Mouton
, WJG Melchers
, PE Verweij

Medical Microbiology & Infectious Diseases

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

We investigated the efficacy of posaconazole prophylaxis in preventing invasive aspergillosis due to azole-resistant Aspergillus fumigatus isolates. Using a neutropenic murine model of pulmonary infection, posaconazole prophylaxis was evaluated using three isogenic clinical isolates, with posaconazole MICs of 0.063 mg/liter (wild type), 0.5 mg/liter (F219I mutation), and 16 mg/liter. A fourth isolate harboring TR34/L98H (MIC of 0.5 mg/liter) was also tested. Posaconazole prophylaxis was effective in A. fumigatus with posaconazole MICs of <= 0.5 mg/liter, where 100% survival was reached. However, breakthrough infection was observed in mice infected with the isolate for which the posaconazole MIC was > 16 mg/liter.

Original language	Undefined/Unknown
Pages (from-to)	1487-1494
Number of pages	8
Journal	Antimicrobial Agents & Chemotherapy
Volume	59
Issue number	3
DOIs	https://doi.org/10.1128/AAC.03850-14
Publication status	Published - 2015

Research programs

EMC MM-04-28-01

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10.1128/AAC.03850-14

http://hdl.handle.net/1765/86243

Cite this

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title = "Posaconazole Prophylaxis in Experimental Azole-Resistant Invasive Pulmonary Aspergillosis",

abstract = "We investigated the efficacy of posaconazole prophylaxis in preventing invasive aspergillosis due to azole-resistant Aspergillus fumigatus isolates. Using a neutropenic murine model of pulmonary infection, posaconazole prophylaxis was evaluated using three isogenic clinical isolates, with posaconazole MICs of 0.063 mg/liter (wild type), 0.5 mg/liter (F219I mutation), and 16 mg/liter. A fourth isolate harboring TR34/L98H (MIC of 0.5 mg/liter) was also tested. Posaconazole prophylaxis was effective in A. fumigatus with posaconazole MICs of <= 0.5 mg/liter, where 100\% survival was reached. However, breakthrough infection was observed in mice infected with the isolate for which the posaconazole MIC was > 16 mg/liter.",

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AU - Verweij, PE

PY - 2015

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