Postconditioning against ischaemia-reperfusion injury: ready for wide application in patients?

T Yetgin; O C Manintveld; D J Duncker; W J van der Giessen

doi:10.1007/BF03091803

Postconditioning against ischaemia-reperfusion injury: ready for wide application in patients?

T Yetgin, O C Manintveld, D J Duncker, W J van der Giessen^*

^*Corresponding author for this work

Cardiology

Interuniversity Cardiology Institute of the Netherlands

Research output: Contribution to journal › Review article › Academic › peer-review

16 Citations (Scopus)

Abstract

Ischaemic postconditioning (IPOC) is an intervention in which brief, intermittent periods of reocclusion at the onset of reperfusion (i.e. stuttering reperfusion) protect myocardium from lethal reperfusion injury. The mechanism underlying the cardioprotective effects of IPOC is incompletely understood. However, it is perceived that IPOC begins with specific cell-surface receptors responsible for activating a number of signalling pathways, many of which appear to converge at the mitochondrial level. IPOC has been demonstrated both in animal models and in patients with acute myocardial infarction (AMI) in small proof-of-concept trials. This intervention offers the possibility of further limiting infarct size in patients undergoing primary percutaneous coronary intervention (PCI). Here, we provide a brief overview of the concept of IPOC and the mechanisms underlying this phenomenon. (Neth Heart J 2010;18:389-93.).

Original language	English
Pages (from-to)	389-92
Number of pages	4
Journal	Netherlands Heart Journal
Volume	18
Issue number	7-8
DOIs	https://doi.org/10.1007/BF03091803
Publication status	Published - Aug 2010

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@article{30bac1724d4a4cde840100a968d83e1c,

title = "Postconditioning against ischaemia-reperfusion injury: ready for wide application in patients?",

abstract = "Ischaemic postconditioning (IPOC) is an intervention in which brief, intermittent periods of reocclusion at the onset of reperfusion (i.e. stuttering reperfusion) protect myocardium from lethal reperfusion injury. The mechanism underlying the cardioprotective effects of IPOC is incompletely understood. However, it is perceived that IPOC begins with specific cell-surface receptors responsible for activating a number of signalling pathways, many of which appear to converge at the mitochondrial level. IPOC has been demonstrated both in animal models and in patients with acute myocardial infarction (AMI) in small proof-of-concept trials. This intervention offers the possibility of further limiting infarct size in patients undergoing primary percutaneous coronary intervention (PCI). Here, we provide a brief overview of the concept of IPOC and the mechanisms underlying this phenomenon. (Neth Heart J 2010;18:389-93.).",

author = "T Yetgin and Manintveld, \{O C\} and Duncker, \{D J\} and \{van der Giessen\}, \{W J\}",

year = "2010",

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doi = "10.1007/BF03091803",

language = "English",

volume = "18",

pages = "389--92",

journal = "Netherlands Heart Journal",

issn = "1568-5888",

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TY - JOUR

T1 - Postconditioning against ischaemia-reperfusion injury

T2 - ready for wide application in patients?

AU - Yetgin, T

AU - Manintveld, O C

AU - Duncker, D J

AU - van der Giessen, W J

PY - 2010/8

Y1 - 2010/8

N2 - Ischaemic postconditioning (IPOC) is an intervention in which brief, intermittent periods of reocclusion at the onset of reperfusion (i.e. stuttering reperfusion) protect myocardium from lethal reperfusion injury. The mechanism underlying the cardioprotective effects of IPOC is incompletely understood. However, it is perceived that IPOC begins with specific cell-surface receptors responsible for activating a number of signalling pathways, many of which appear to converge at the mitochondrial level. IPOC has been demonstrated both in animal models and in patients with acute myocardial infarction (AMI) in small proof-of-concept trials. This intervention offers the possibility of further limiting infarct size in patients undergoing primary percutaneous coronary intervention (PCI). Here, we provide a brief overview of the concept of IPOC and the mechanisms underlying this phenomenon. (Neth Heart J 2010;18:389-93.).

AB - Ischaemic postconditioning (IPOC) is an intervention in which brief, intermittent periods of reocclusion at the onset of reperfusion (i.e. stuttering reperfusion) protect myocardium from lethal reperfusion injury. The mechanism underlying the cardioprotective effects of IPOC is incompletely understood. However, it is perceived that IPOC begins with specific cell-surface receptors responsible for activating a number of signalling pathways, many of which appear to converge at the mitochondrial level. IPOC has been demonstrated both in animal models and in patients with acute myocardial infarction (AMI) in small proof-of-concept trials. This intervention offers the possibility of further limiting infarct size in patients undergoing primary percutaneous coronary intervention (PCI). Here, we provide a brief overview of the concept of IPOC and the mechanisms underlying this phenomenon. (Neth Heart J 2010;18:389-93.).

U2 - 10.1007/BF03091803

DO - 10.1007/BF03091803

M3 - Review article

C2 - 20730014

SN - 1568-5888

VL - 18

SP - 389

EP - 392

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

IS - 7-8

ER -

Postconditioning against ischaemia-reperfusion injury: ready for wide application in patients?

Abstract

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