Potential role of type I interferons in the treatment of pituitary adenomas

G (Giovanni) Vitale; M Caraglia; Peter van Koetsveld; P Maroni; M Marra; A Colao; S.W.J. Lamberts; F Cavagnini; Leo Hofland

doi:10.1007/s11154-008-9083-3

Potential role of type I interferons in the treatment of pituitary adenomas

G (Giovanni) Vitale, M Caraglia, Peter van Koetsveld, P Maroni, M Marra, A Colao, S.W.J. Lamberts, F Cavagnini, Leo Hofland

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-alpha and IFN-beta on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.

Original language	Undefined/Unknown
Pages (from-to)	125-133
Number of pages	9
Journal	Reviews in Endocrine & Metabolic Disorders
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s11154-008-9083-3
Publication status	Published - 2009

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EMC MM-01-39-01

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11154-008-9083-3

http://hdl.handle.net/1765/26965

Cite this

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title = "Potential role of type I interferons in the treatment of pituitary adenomas",

abstract = "Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-alpha and IFN-beta on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.",

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T1 - Potential role of type I interferons in the treatment of pituitary adenomas

AU - Vitale, G (Giovanni)

AU - Caraglia, M

AU - van Koetsveld, Peter

AU - Maroni, P

AU - Marra, M

AU - Colao, A

AU - Lamberts, S.W.J.

AU - Cavagnini, F

AU - Hofland, Leo

PY - 2009

Y1 - 2009

N2 - Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-alpha and IFN-beta on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.

AB - Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-alpha and IFN-beta on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.

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DO - 10.1007/s11154-008-9083-3

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