Pre-operative diagnostic biopsy and surgery in paediatric liver tumours: The Amsterdam experience

J. M. Schnater, C. F. Kuijper, J. Zsiros, H. A. Heij, D. C. Aronson*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Abstract

Aim: To report 24 years of pre-treatment biopsy and surgical experience in primary liver tumours in children. Methods: Between 1979 and 2003, 53 children presented with a primary liver tumour of whom 48 who underwent surgical resection were evaluated (two died, two were unresectable, and one was transplanted). Biopsy data, per- and post-operative complications, mortality, and survival were retrospectively reviewed. Results: Benign tumours were diagnosed in eight patients. Surgical resection for a malignant tumour was performed in 40 patients (26 hepatoblastomas (HB), eight hepatocellular carcinomas (HCC) (four had fibrolamellar HCC), three rhabdomyosarcomas (RMS), one neuroblastoma, one non-hodgkin lymphoma (NHL), and one teratoma). Primary resection was performed in one HB, and four HCCs. The cumulative survival without evidence of disease was 73% for HB (median 7 years) and 88% for HCC (median 3.5 years). Conclusion: The treatment results are comparable with those of larger international series except for HCC. The existing diagnostic pitfalls in differentiating between the various liver malignancies justify the use of a diagnostic biopsy.

Original languageEnglish
Pages (from-to)1160-1165
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume31
Issue number10
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

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