Preclinical studies in small animals for advanced drug delivery using hyperthermia and intravital microscopy

Marjolein I. Priester, Sergio Curto, Ann L.B. Seynhaeve, Anderson Cruz Perdomo, Mohamadreza Amin, Pierre Agnass, Milad Salimibani, Pegah Faridi, Punit Prakash, Gerard C. van Rhoon, Timo L.M. Ten Hagen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

This paper presents three devices suitable for the preclinical application of hyperthermia via the simultaneous high-resolution imaging of intratumoral events. (Pre)clinical studies have con-firmed that the tumor micro-environment is sensitive to the application of local mild hyperthermia. Therefore, heating is a promising adjuvant to aid the efficacy of radiotherapy or chemotherapy. More so, the application of mild hyperthermia is a useful stimulus for triggered drug release from heat-sensitive nanocarriers. The response of thermosensitive nanoparticles to hyperthermia and en-suing intratumoral kinetics are considerably complex in both space and time. To obtain better insight into intratumoral processes, longitudinal imaging (preferable in high spatial and temporal resolution) is highly informative. Our devices are based on (i) an external electric heating adaptor for the dorsal skinfold model, (ii) targeted radiofrequency application, and (iii) a microwave an-tenna for heating of internal tumors. These models, while of some technical complexity, significantly add to the understanding of effects of mild hyperthermia warranting implementation in research on hyperthermia.

Original languageEnglish
Article number5146
JournalCancers
Volume13
Issue number20
DOIs
Publication statusPublished - 14 Oct 2021

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