Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome

Ángela Domingo-Santos; Andrés Labiano-Fontcuberta; Yolanda Aladro-Benito; M. Luisa Martínez-Ginés; Lucía Ayuso-Peralta; Verónica Puertas-Martín; Marta Cerezo-García; Yolanda Higueras-Hernández; Virginia Mato-Abad; Juan Álvarez-Linera; Juan Antonio Hernández-Tamames; Julián Benito-León

doi:10.1016/j.msard.2021.102749

Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome

Ángela Domingo-Santos^*, Andrés Labiano-Fontcuberta, Yolanda Aladro-Benito, M. Luisa Martínez-Ginés, Lucía Ayuso-Peralta, Verónica Puertas-Martín, Marta Cerezo-García, Yolanda Higueras-Hernández, Virginia Mato-Abad, Juan Álvarez-Linera, Juan Antonio Hernández-Tamames, Julián Benito-León

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Up to a third of patients with radiologically isolated syndrome (RIS) exhibit lower-than-expected cognitive performances in neuropsychological evaluations, but the relationship between cognitive impairment (CI) and quantitative magnetic resonance (MRI) measures has not been stablished. Furthermore, the prognostic role of CI in RIS for conversion to MS is currently unknown. We assessed 17 patients with RIS and 17 matched healthy controls (HC) with a neurophychological battery and a 3T MRI. Six patients (35,3%) fulfilled our criterion for CI (scores 2 SDs below the mean of HC in at least two cognitive tests) (ci-RIS). The ci-RIS subgroup showed lower values of normalized brain and gray matter volumes when compared to HC. After a median follow-up time of 4.5 years, the ci-RIS subgroup presented a higher conversion rate to MS, suggesting that CI might be an independent risk factor for conversion to MS.

Original language	English
Article number	102749
Journal	Multiple Sclerosis and Related Disorders
Volume	49
DOIs	https://doi.org/10.1016/j.msard.2021.102749
Publication status	Published - Apr 2021
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by Teva neuroscience and FEDER funds. Dr. Benito-León is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS #R01 NS39422), the Commission of the European Union (grant ICT-2011–287739, NeuroTREMOR), the Ministry of Economy and Competitiveness (grant RTC-2015–3967-1, NetMD—Platform for the tracking of movement disorders), and the Spanish Health Research Agency (grant FIS PI12/01602).

Publisher Copyright:
© 2021

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Domingo-Santos, Á., Labiano-Fontcuberta, A., Aladro-Benito, Y., Martínez-Ginés, M. L., Ayuso-Peralta, L., Puertas-Martín, V., Cerezo-García, M., Higueras-Hernández, Y., Mato-Abad, V., Álvarez-Linera, J., Hernández-Tamames, J. A., & Benito-León, J. (2021). Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome. Multiple Sclerosis and Related Disorders, 49, Article 102749. https://doi.org/10.1016/j.msard.2021.102749

@article{163be0be56744d588cb5b32be4997706,

title = "Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome",

abstract = "Up to a third of patients with radiologically isolated syndrome (RIS) exhibit lower-than-expected cognitive performances in neuropsychological evaluations, but the relationship between cognitive impairment (CI) and quantitative magnetic resonance (MRI) measures has not been stablished. Furthermore, the prognostic role of CI in RIS for conversion to MS is currently unknown. We assessed 17 patients with RIS and 17 matched healthy controls (HC) with a neurophychological battery and a 3T MRI. Six patients (35,3%) fulfilled our criterion for CI (scores 2 SDs below the mean of HC in at least two cognitive tests) (ci-RIS). The ci-RIS subgroup showed lower values of normalized brain and gray matter volumes when compared to HC. After a median follow-up time of 4.5 years, the ci-RIS subgroup presented a higher conversion rate to MS, suggesting that CI might be an independent risk factor for conversion to MS.",

author = "{\'A}ngela Domingo-Santos and Andr{\'e}s Labiano-Fontcuberta and Yolanda Aladro-Benito and Mart{\'i}nez-Gin{\'e}s, {M. Luisa} and Luc{\'i}a Ayuso-Peralta and Ver{\'o}nica Puertas-Mart{\'i}n and Marta Cerezo-Garc{\'i}a and Yolanda Higueras-Hern{\'a}ndez and Virginia Mato-Abad and Juan {\'A}lvarez-Linera and Hern{\'a}ndez-Tamames, {Juan Antonio} and Juli{\'a}n Benito-Le{\'o}n",

note = "Funding Information: This research was supported by Teva neuroscience and FEDER funds. Dr. Benito-Le{\'o}n is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS #R01 NS39422), the Commission of the European Union (grant ICT-2011–287739, NeuroTREMOR), the Ministry of Economy and Competitiveness (grant RTC-2015–3967-1, NetMD—Platform for the tracking of movement disorders), and the Spanish Health Research Agency (grant FIS PI12/01602). Publisher Copyright: {\textcopyright} 2021",

year = "2021",

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doi = "10.1016/j.msard.2021.102749",

language = "English",

volume = "49",

journal = "Multiple Sclerosis and Related Disorders",

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Domingo-Santos, Á, Labiano-Fontcuberta, A, Aladro-Benito, Y, Martínez-Ginés, ML, Ayuso-Peralta, L, Puertas-Martín, V, Cerezo-García, M, Higueras-Hernández, Y, Mato-Abad, V, Álvarez-Linera, J, Hernández-Tamames, JA & Benito-León, J 2021, 'Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome', Multiple Sclerosis and Related Disorders, vol. 49, 102749. https://doi.org/10.1016/j.msard.2021.102749

TY - JOUR

T1 - Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome

AU - Domingo-Santos, Ángela

AU - Labiano-Fontcuberta, Andrés

AU - Aladro-Benito, Yolanda

AU - Martínez-Ginés, M. Luisa

AU - Ayuso-Peralta, Lucía

AU - Puertas-Martín, Verónica

AU - Cerezo-García, Marta

AU - Higueras-Hernández, Yolanda

AU - Mato-Abad, Virginia

AU - Álvarez-Linera, Juan

AU - Hernández-Tamames, Juan Antonio

AU - Benito-León, Julián

N1 - Funding Information: This research was supported by Teva neuroscience and FEDER funds. Dr. Benito-León is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS #R01 NS39422), the Commission of the European Union (grant ICT-2011–287739, NeuroTREMOR), the Ministry of Economy and Competitiveness (grant RTC-2015–3967-1, NetMD—Platform for the tracking of movement disorders), and the Spanish Health Research Agency (grant FIS PI12/01602). Publisher Copyright: © 2021

PY - 2021/4

Y1 - 2021/4

N2 - Up to a third of patients with radiologically isolated syndrome (RIS) exhibit lower-than-expected cognitive performances in neuropsychological evaluations, but the relationship between cognitive impairment (CI) and quantitative magnetic resonance (MRI) measures has not been stablished. Furthermore, the prognostic role of CI in RIS for conversion to MS is currently unknown. We assessed 17 patients with RIS and 17 matched healthy controls (HC) with a neurophychological battery and a 3T MRI. Six patients (35,3%) fulfilled our criterion for CI (scores 2 SDs below the mean of HC in at least two cognitive tests) (ci-RIS). The ci-RIS subgroup showed lower values of normalized brain and gray matter volumes when compared to HC. After a median follow-up time of 4.5 years, the ci-RIS subgroup presented a higher conversion rate to MS, suggesting that CI might be an independent risk factor for conversion to MS.

AB - Up to a third of patients with radiologically isolated syndrome (RIS) exhibit lower-than-expected cognitive performances in neuropsychological evaluations, but the relationship between cognitive impairment (CI) and quantitative magnetic resonance (MRI) measures has not been stablished. Furthermore, the prognostic role of CI in RIS for conversion to MS is currently unknown. We assessed 17 patients with RIS and 17 matched healthy controls (HC) with a neurophychological battery and a 3T MRI. Six patients (35,3%) fulfilled our criterion for CI (scores 2 SDs below the mean of HC in at least two cognitive tests) (ci-RIS). The ci-RIS subgroup showed lower values of normalized brain and gray matter volumes when compared to HC. After a median follow-up time of 4.5 years, the ci-RIS subgroup presented a higher conversion rate to MS, suggesting that CI might be an independent risk factor for conversion to MS.

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U2 - 10.1016/j.msard.2021.102749

DO - 10.1016/j.msard.2021.102749

M3 - Article

C2 - 33486398

AN - SCOPUS:85099610271

SN - 2211-0348

VL - 49

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

M1 - 102749

ER -

Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome

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