Prediction model and prognostic index to estimate clinically relevant pelvic organ prolapse in a general female population

Marijke Hove, Annelies Goudzwaard, Rene Eijkemans, Régine Steegers - Theunissen, Curt Burger, ME (Mark) Vierhout

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Estimation on prevalence and distribution of pelvic organ prolapse (POP) signs in a general female population is difficult. We therefore developed and validated a prediction model and prognostic instrument. Questionnaires were sent to a general female population (45-85 years). A random sample underwent vaginal examination for POP (POPQ). A prediction model was developed using multivariate analysis and validated in a subgroup of participants. Positive questionnaire-response rate was 46.8% (1,397 of 2,979). From the questionnaire group, 649 women were vaginally examined (46.5%). Prevalence of clinically relevant POP was 21%. Multivariate analysis demonstrated significantly higher odds ratios on the report of vaginal bulging, parity a parts per thousand yen2 and a mother with POP. The receiver operating characteristic curve showed areas under the curve of 0.672 and 0.640. The prevalence of POP at or beyond the hymen could be estimated in a general female population using our prediction model with 17 questions and our POP score chart with eight questions.
Original languageUndefined/Unknown
Pages (from-to)1013-1021
Number of pages9
JournalInternational Urogynecology Journal and Pelvic Floor Dysfunction
Issue number9
Publication statusPublished - 2009

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