Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm

Raquel Costa; Adrien M. Aubert; The SHIPS research group; Anna Veera Seppänen; U. Aden; I. Sarrechia; M. Zemlin; M. Cuttini; M. Männamaa; V. Pierrat; A. van Heijst; H. Barros; Jennifer Zeitlin; Samantha Johnson; V. Carnielli

doi:10.1111/dmcn.15518

Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm

Raquel Costa^*, Adrien M. Aubert, The SHIPS research group, Anna Veera Seppänen, U. Aden, I. Sarrechia, M. Zemlin, M. Cuttini, M. Männamaa, V. Pierrat, A. van Heijst, H. Barros, Jennifer Zeitlin, Samantha Johnson, V. Carnielli

^*Corresponding author for this work

Pediatric Surgery

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aim: To assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. Method: Data were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable to walk unassisted at 2 years corrected age. Examiners assessed significant movement difficulties (score ≤ 5th centile on the Movement Assessment Battery for Children, Second Edition) and diagnoses of cerebral palsy (CP) were collected by parent report at 5 years chronological age. Results: At 2 years, 66 (11.9%) children had moderate/severe GMI. At 5 years, 212 (38.1%) had significant movement difficulties. Parent reports of GMI at age 2 years accurately classified CP at age 5 years in 91.0% to 93.2% of children. Classification of moderate/severe GMI at age 2 years had high specificity (96.2%; 95% confidence interval 93.6–98.0) and positive predictive value (80.3%; 68.7–89.1) for significant movement difficulties at age 5 years. However, 74.5% of children with significant movement difficulties at 5 years were not identified with moderate/severe GMI at age 2 years, resulting in low sensitivity (25.1%; 19.4–31.5). Interpretation: This questionnaire may be used to identify children born extremely preterm who at age 2 years have a diagnosis of CP or movement difficulties that are likely to have a significant impact on their functional outcomes at age 5 years.

Original language	English
Pages (from-to)	1215-1225
Number of pages	11
Journal	Developmental Medicine and Child Neurology
Volume	65
Issue number	9
DOIs	https://doi.org/10.1111/dmcn.15518
Publication status	Published - Sept 2023

Bibliographical note

Funding Information:
The European Union's Seventh Framework Program ([FP7/2007–2013]) under grant agreement 259882 and the European Union's Horizon 2020 research and innovation program under grant agreement 633724; in Portugal by the FSE and FCT – Fundação para a Ciência e a Tecnologia, I.P. (UIDB/04750/2020 [EPIUnit]; LA/P/0064/2020 [ITR]; Post‐Doctoral Grant SFRH/BPD/117597/2016 [RC]); in France by the French National Institute of Public Health Research (IRESP TGIR 2009–01 programme)/Institute of Public Health and its partners (the French Health Ministry, the National Institute of Health and Medical Research [INSERM], the National Institute of Cancer, the National Solidarity Fund for Autonomy [CNSA]), the National Research Agency through the French EQUIPEX program of investments for the future (grant no. ANR‐11‐EQPX‐0038), and the PremUp Foundation; in Poland by the 2016–2019 allocation of funds for international projects from the Polish Ministry of Science and Higher Education; in Sweden by the Swedish Medical Research Council (grant number 2017–03043) and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet (grant ALF SLL 20170243). The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.

Funding Information:
The members of the SHIPS research group are as follows: Belgium (J Lebeer, I Sarrechia, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus); Denmark (K Boerch, P Pedersen); Estonia (L Toome, H Varendi, M Männamaa); France (P Y Ancel, A Burguet, P H Jarreau, V Pierrat, A Nuytten); Germany (R F Maier, M Zemlin, B Misselwitz, L Wohlers) Italy (M Cuttini, I Croci, V Carnielli, G Ancora, A. Sansavini, G Faldella, F Ferrari); the Netherlands (A van Heijst, C Koopman-Esseboom); Poland (J Gadzinowski, J Mazela, A Montgomery, T Pikuła) Portugal (H Barros, R Costa, C Rodrigues); Sweden (U Aden); UK (E S Draper, A Fenton, S J Johnson); European Foundation for the Care of Newborn Infants (S Mader, N Thiele, J M Pfeil); Health Economics team (S Petrou, S W Kim, L Andronis); Inserm Coordination (J Zeitlin, A M Aubert, C Bonnet, R El Rafei, A V Seppänen).

Publisher Copyright:
© 2023 Mac Keith Press.

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Costa, R., Aubert, A. M., The SHIPS research group, Seppänen, A. V., Aden, U., Sarrechia, I., Zemlin, M., Cuttini, M., Männamaa, M., Pierrat, V., van Heijst, A., Barros, H., Zeitlin, J., Johnson, S., & Carnielli, V. (2023). Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm. Developmental Medicine and Child Neurology, 65(9), 1215-1225. https://doi.org/10.1111/dmcn.15518

@article{256e1fad444845a3b7bffd30cc425467,

title = "Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm",

abstract = "Aim: To assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. Method: Data were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable to walk unassisted at 2 years corrected age. Examiners assessed significant movement difficulties (score ≤ 5th centile on the Movement Assessment Battery for Children, Second Edition) and diagnoses of cerebral palsy (CP) were collected by parent report at 5 years chronological age. Results: At 2 years, 66 (11.9%) children had moderate/severe GMI. At 5 years, 212 (38.1%) had significant movement difficulties. Parent reports of GMI at age 2 years accurately classified CP at age 5 years in 91.0% to 93.2% of children. Classification of moderate/severe GMI at age 2 years had high specificity (96.2%; 95% confidence interval 93.6–98.0) and positive predictive value (80.3%; 68.7–89.1) for significant movement difficulties at age 5 years. However, 74.5% of children with significant movement difficulties at 5 years were not identified with moderate/severe GMI at age 2 years, resulting in low sensitivity (25.1%; 19.4–31.5). Interpretation: This questionnaire may be used to identify children born extremely preterm who at age 2 years have a diagnosis of CP or movement difficulties that are likely to have a significant impact on their functional outcomes at age 5 years.",

author = "Raquel Costa and Aubert, {Adrien M.} and {The SHIPS research group} and Sepp{\"a}nen, {Anna Veera} and U. Aden and I. Sarrechia and M. Zemlin and M. Cuttini and M. M{\"a}nnamaa and V. Pierrat and {van Heijst}, A. and H. Barros and Jennifer Zeitlin and Samantha Johnson and J. Lebeer and I. Sarrechia and {Van Reempts}, P. and E. Bruneel and E. Cloet and A. Oostra and E. Ortibus and K. Boerch and P. Pedersen and L. Toome and H. Varendi and M. M{\"a}nnamaa and Ancel, {P. Y.} and A. Burguet and Jarreau, {P. H.} and V. Pierrat and A. Nuytten and Maier, {R. F.} and M. Zemlin and B. Misselwitz and L. Wohlers and M. Cuttini and I. Croci and V. Carnielli and G. Ancora and A. Sansavini and G. Faldella and F. Ferrari and {van Heijst}, A. and C. Koopman-Esseboom and J. Gadzinowski and J. Mazela and A. Montgomery and T. Piku{\l}a and H. Barros",

note = "Funding Information: The European Union's Seventh Framework Program ([FP7/2007–2013]) under grant agreement 259882 and the European Union's Horizon 2020 research and innovation program under grant agreement 633724; in Portugal by the FSE and FCT – Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, I.P. (UIDB/04750/2020 [EPIUnit]; LA/P/0064/2020 [ITR]; Post‐Doctoral Grant SFRH/BPD/117597/2016 [RC]); in France by the French National Institute of Public Health Research (IRESP TGIR 2009–01 programme)/Institute of Public Health and its partners (the French Health Ministry, the National Institute of Health and Medical Research [INSERM], the National Institute of Cancer, the National Solidarity Fund for Autonomy [CNSA]), the National Research Agency through the French EQUIPEX program of investments for the future (grant no. ANR‐11‐EQPX‐0038), and the PremUp Foundation; in Poland by the 2016–2019 allocation of funds for international projects from the Polish Ministry of Science and Higher Education; in Sweden by the Swedish Medical Research Council (grant number 2017–03043) and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet (grant ALF SLL 20170243). The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Funding Information: The members of the SHIPS research group are as follows: Belgium (J Lebeer, I Sarrechia, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus); Denmark (K Boerch, P Pedersen); Estonia (L Toome, H Varendi, M M{\"a}nnamaa); France (P Y Ancel, A Burguet, P H Jarreau, V Pierrat, A Nuytten); Germany (R F Maier, M Zemlin, B Misselwitz, L Wohlers) Italy (M Cuttini, I Croci, V Carnielli, G Ancora, A. Sansavini, G Faldella, F Ferrari); the Netherlands (A van Heijst, C Koopman-Esseboom); Poland (J Gadzinowski, J Mazela, A Montgomery, T Piku{\l}a) Portugal (H Barros, R Costa, C Rodrigues); Sweden (U Aden); UK (E S Draper, A Fenton, S J Johnson); European Foundation for the Care of Newborn Infants (S Mader, N Thiele, J M Pfeil); Health Economics team (S Petrou, S W Kim, L Andronis); Inserm Coordination (J Zeitlin, A M Aubert, C Bonnet, R El Rafei, A V Sepp{\"a}nen). Publisher Copyright: {\textcopyright} 2023 Mac Keith Press.",

year = "2023",

month = sep,

doi = "10.1111/dmcn.15518",

language = "English",

volume = "65",

pages = "1215--1225",

journal = "Developmental Medicine and Child Neurology",

issn = "0012-1622",

publisher = "Wiley-Blackwell",

number = "9",

}

Costa, R, Aubert, AM, The SHIPS research group, Seppänen, AV, Aden, U, Sarrechia, I, Zemlin, M, Cuttini, M, Männamaa, M, Pierrat, V, van Heijst, A, Barros, H, Zeitlin, J, Johnson, S & Carnielli, V 2023, 'Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm', Developmental Medicine and Child Neurology, vol. 65, no. 9, pp. 1215-1225. https://doi.org/10.1111/dmcn.15518

TY - JOUR

T1 - Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm

AU - Costa, Raquel

AU - Aubert, Adrien M.

AU - The SHIPS research group

AU - Seppänen, Anna Veera

AU - Aden, U.

AU - Sarrechia, I.

AU - Zemlin, M.

AU - Cuttini, M.

AU - Männamaa, M.

AU - Pierrat, V.

AU - van Heijst, A.

AU - Barros, H.

AU - Zeitlin, Jennifer

AU - Johnson, Samantha

AU - Lebeer, J.

AU - Sarrechia, I.

AU - Van Reempts, P.

AU - Bruneel, E.

AU - Cloet, E.

AU - Oostra, A.

AU - Ortibus, E.

AU - Boerch, K.

AU - Pedersen, P.

AU - Toome, L.

AU - Varendi, H.

AU - Männamaa, M.

AU - Ancel, P. Y.

AU - Burguet, A.

AU - Jarreau, P. H.

AU - Pierrat, V.

AU - Nuytten, A.

AU - Maier, R. F.

AU - Zemlin, M.

AU - Misselwitz, B.

AU - Wohlers, L.

AU - Cuttini, M.

AU - Croci, I.

AU - Carnielli, V.

AU - Ancora, G.

AU - Sansavini, A.

AU - Faldella, G.

AU - Ferrari, F.

AU - van Heijst, A.

AU - Koopman-Esseboom, C.

AU - Gadzinowski, J.

AU - Mazela, J.

AU - Montgomery, A.

AU - Pikuła, T.

AU - Barros, H.

N1 - Funding Information: The European Union's Seventh Framework Program ([FP7/2007–2013]) under grant agreement 259882 and the European Union's Horizon 2020 research and innovation program under grant agreement 633724; in Portugal by the FSE and FCT – Fundação para a Ciência e a Tecnologia, I.P. (UIDB/04750/2020 [EPIUnit]; LA/P/0064/2020 [ITR]; Post‐Doctoral Grant SFRH/BPD/117597/2016 [RC]); in France by the French National Institute of Public Health Research (IRESP TGIR 2009–01 programme)/Institute of Public Health and its partners (the French Health Ministry, the National Institute of Health and Medical Research [INSERM], the National Institute of Cancer, the National Solidarity Fund for Autonomy [CNSA]), the National Research Agency through the French EQUIPEX program of investments for the future (grant no. ANR‐11‐EQPX‐0038), and the PremUp Foundation; in Poland by the 2016–2019 allocation of funds for international projects from the Polish Ministry of Science and Higher Education; in Sweden by the Swedish Medical Research Council (grant number 2017–03043) and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet (grant ALF SLL 20170243). The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Funding Information: The members of the SHIPS research group are as follows: Belgium (J Lebeer, I Sarrechia, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus); Denmark (K Boerch, P Pedersen); Estonia (L Toome, H Varendi, M Männamaa); France (P Y Ancel, A Burguet, P H Jarreau, V Pierrat, A Nuytten); Germany (R F Maier, M Zemlin, B Misselwitz, L Wohlers) Italy (M Cuttini, I Croci, V Carnielli, G Ancora, A. Sansavini, G Faldella, F Ferrari); the Netherlands (A van Heijst, C Koopman-Esseboom); Poland (J Gadzinowski, J Mazela, A Montgomery, T Pikuła) Portugal (H Barros, R Costa, C Rodrigues); Sweden (U Aden); UK (E S Draper, A Fenton, S J Johnson); European Foundation for the Care of Newborn Infants (S Mader, N Thiele, J M Pfeil); Health Economics team (S Petrou, S W Kim, L Andronis); Inserm Coordination (J Zeitlin, A M Aubert, C Bonnet, R El Rafei, A V Seppänen). Publisher Copyright: © 2023 Mac Keith Press.

PY - 2023/9

Y1 - 2023/9

N2 - Aim: To assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. Method: Data were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable to walk unassisted at 2 years corrected age. Examiners assessed significant movement difficulties (score ≤ 5th centile on the Movement Assessment Battery for Children, Second Edition) and diagnoses of cerebral palsy (CP) were collected by parent report at 5 years chronological age. Results: At 2 years, 66 (11.9%) children had moderate/severe GMI. At 5 years, 212 (38.1%) had significant movement difficulties. Parent reports of GMI at age 2 years accurately classified CP at age 5 years in 91.0% to 93.2% of children. Classification of moderate/severe GMI at age 2 years had high specificity (96.2%; 95% confidence interval 93.6–98.0) and positive predictive value (80.3%; 68.7–89.1) for significant movement difficulties at age 5 years. However, 74.5% of children with significant movement difficulties at 5 years were not identified with moderate/severe GMI at age 2 years, resulting in low sensitivity (25.1%; 19.4–31.5). Interpretation: This questionnaire may be used to identify children born extremely preterm who at age 2 years have a diagnosis of CP or movement difficulties that are likely to have a significant impact on their functional outcomes at age 5 years.

AB - Aim: To assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. Method: Data were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable to walk unassisted at 2 years corrected age. Examiners assessed significant movement difficulties (score ≤ 5th centile on the Movement Assessment Battery for Children, Second Edition) and diagnoses of cerebral palsy (CP) were collected by parent report at 5 years chronological age. Results: At 2 years, 66 (11.9%) children had moderate/severe GMI. At 5 years, 212 (38.1%) had significant movement difficulties. Parent reports of GMI at age 2 years accurately classified CP at age 5 years in 91.0% to 93.2% of children. Classification of moderate/severe GMI at age 2 years had high specificity (96.2%; 95% confidence interval 93.6–98.0) and positive predictive value (80.3%; 68.7–89.1) for significant movement difficulties at age 5 years. However, 74.5% of children with significant movement difficulties at 5 years were not identified with moderate/severe GMI at age 2 years, resulting in low sensitivity (25.1%; 19.4–31.5). Interpretation: This questionnaire may be used to identify children born extremely preterm who at age 2 years have a diagnosis of CP or movement difficulties that are likely to have a significant impact on their functional outcomes at age 5 years.

UR - http://www.scopus.com/inward/record.url?scp=85148757341&partnerID=8YFLogxK

U2 - 10.1111/dmcn.15518

DO - 10.1111/dmcn.15518

M3 - Article

C2 - 38038478

AN - SCOPUS:85148757341

SN - 0012-1622

VL - 65

SP - 1215

EP - 1225

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

IS - 9

ER -

Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm

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