Predictive Value of Multislice Computed Tomography Variables of Atherosclerosis for Ischemia on Stress-Rest Single-Photon Emission Computed Tomography

JE Velzen, JD Schuijf, JM van Werkhoven, BA Herzog, AP Pazhenkottil, Eric Boersma, FR de Graaf, AJ Scholte, LJ Kroft, A de Roos, MP Stokkel, JW Jukema, PA Kaufmann, EE van der Wall, JJ Bax

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Background-Previous studies have shown that the presence of stenosis alone on multislice computed tomography (MSCT) has a limited positive predictive value for the presence of ischemia on myocardial perfusion imaging (MPI). The purpose of this study was to assess which variables of atherosclerosis on MSCT angiography are related to ischemia on MPI. Methods and Results-Both MSCT and MPI were performed in 514 patients. On MSCT, the calcium score, degree of stenosis (>= 50% and >= 70% stenosis), and plaque extent and location were determined. Plaque composition was classified as noncalcified, mixed, or calcified. Ischemia was defined as a summed difference score (>= 2 on a per-patient basis. Ischemia was observed in 137 patients (27%). On a per-patient basis, multivariate analysis showed that the degree of stenosis (presence of (>= 70% stenosis, odds ratio=3.5), plaque extent and composition (mixed plaques (>= 3, odds ratio=1.7; calcified plaques >= 3, odds ratio=2.0), and location (atherosclerotic disease in the left main coronary artery and/or proximal left anterior descending coronary artery, odds ratio=1.6) were independent predictors for ischemia on MPI. In addition, MSCT variables of atherosclerosis, such as plaque extent, composition, and location, had significant incremental value for the prediction of ischemia over the presence of >= 70% stenosis. Conclusions-In addition to the degree of stenosis, MSCT variables of atherosclerosis describing plaque extent, composition, and location are predictive of the presence of ischemia on MPI. (Circ Cardiovasc Imaging. 2010; 3: 718-726.)
Original languageUndefined/Unknown
Pages (from-to)718-726
Number of pages9
JournalCirculation Cardiovascular Imaging
Issue number6
Publication statusPublished - 2010

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