TY - JOUR
T1 - Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18
AU - Melidou, Angeliki
AU - Broberg, Eeva
AU - European region influenza surveillance network
AU - Redlberger-Fritz, Monika
AU - Popow-Kraupp, Therese
AU - Thomas, Isabelle
AU - Barbezange, Cyril
AU - Bossuyt, Nathalie
AU - Jirincova, Helena
AU - Nagy, Alexander
AU - Trebbien, Ramona
AU - Fischer, Thea K.
AU - Ikonen, Niina
AU - Haveri, Anu
AU - Lyytikäinen, Outi
AU - Murtopuro, Satu
AU - Behillil, Sylvie
AU - Enouf, Vincent
AU - Van Der Werf, Sylvie
AU - Falchi, Alessandra
AU - Valette, Martine
AU - Lina, Bruno
AU - Schweiger, Brunhilde
AU - Biere, Barbara
AU - Duwe, Susanne
AU - Wedde, Marianne
AU - Buda, Silke
AU - Mentis, Andreas
AU - Kossyvakis, Athanasios
AU - Pogka, Vasiliki
AU - Papa-Konidari, Anna
AU - Gioula, Georgia
AU - Exindari, Maria
AU - Dunford, Linda
AU - Connell, Jeff
AU - Tuite, Grainne
AU - Duffy, Margaret
AU - Moran, Joanne
AU - Hogg, Bridget
AU - Waters, Allison
AU - De Gas-Cun, Cillian
AU - Domegan, Lisa
AU - O'Donnell, Joan
AU - Joyce, Michael
AU - Castrucci, Maria Rita
AU - Puzelli, Simona
AU - Rizzo, Caterina
AU - Bella, Anto Nino
AU - Meijer, Adam
AU - Van Beek, Ruud
AU - Koopmans, Marion
AU - Rimmelzwaan, Guus
N1 - Publisher Copyright:
© 2017
PY - 2017/9/5
Y1 - 2017/9/5
N2 - During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.
AB - During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.
UR - http://www.scopus.com/inward/record.url?scp=85028069868&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2017.07.057
DO - 10.1016/j.vaccine.2017.07.057
M3 - Article
C2 - 28780977
AN - SCOPUS:85028069868
VL - 35
SP - 4828
EP - 4835
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 37
ER -
