Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands

S. Bulk; J. Berkhof; N. W.J. Bulkmans; G. D. Zielinski; L. Rozendaal; F. J. Van Kemenade; P. J.F. Snijders; C. J.L.M. Meijer

doi:10.1038/sj.bjc.6602915

Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands

S. Bulk, J. Berkhof, N. W.J. Bulkmans, G. D. Zielinski, L. Rozendaal, F. J. Van Kemenade, P. J.F. Snijders, C. J.L.M. Meijer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n = 1467), adenocarcinoma in situ (ACIS) (n = 61), adenocarcinoma (n = 70), and squamous cell carcinoma (SCC) (n = 83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (OR_MH 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus 16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR _MH 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (OR_MH 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (OR_MH 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.

Original language	English
Pages (from-to)	171-175
Number of pages	5
Journal	British Journal of Cancer
Volume	94
Issue number	1
DOIs	https://doi.org/10.1038/sj.bjc.6602915
Publication status	Published - 16 Jan 2006
Externally published	Yes

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Bulk, S., Berkhof, J., Bulkmans, N. W. J., Zielinski, G. D., Rozendaal, L., Van Kemenade, F. J., Snijders, P. J. F., & Meijer, C. J. L. M. (2006). Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands. British Journal of Cancer, 94(1), 171-175. https://doi.org/10.1038/sj.bjc.6602915

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title = "Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands",

abstract = "We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n = 1467), adenocarcinoma in situ (ACIS) (n = 61), adenocarcinoma (n = 70), and squamous cell carcinoma (SCC) (n = 83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (ORMH 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus 16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR MH 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (ORMH 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (ORMH 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.",

author = "S. Bulk and J. Berkhof and Bulkmans, {N. W.J.} and Zielinski, {G. D.} and L. Rozendaal and {Van Kemenade}, {F. J.} and Snijders, {P. J.F.} and Meijer, {C. J.L.M.}",

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Bulk, S, Berkhof, J, Bulkmans, NWJ, Zielinski, GD, Rozendaal, L, Van Kemenade, FJ, Snijders, PJF & Meijer, CJLM 2006, 'Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands', British Journal of Cancer, vol. 94, no. 1, pp. 171-175. https://doi.org/10.1038/sj.bjc.6602915

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T1 - Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands

AU - Bulk, S.

AU - Berkhof, J.

AU - Bulkmans, N. W.J.

AU - Zielinski, G. D.

AU - Rozendaal, L.

AU - Van Kemenade, F. J.

AU - Snijders, P. J.F.

AU - Meijer, C. J.L.M.

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N2 - We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n = 1467), adenocarcinoma in situ (ACIS) (n = 61), adenocarcinoma (n = 70), and squamous cell carcinoma (SCC) (n = 83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (ORMH 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus 16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR MH 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (ORMH 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (ORMH 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.

AB - We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n = 1467), adenocarcinoma in situ (ACIS) (n = 61), adenocarcinoma (n = 70), and squamous cell carcinoma (SCC) (n = 83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (ORMH 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus 16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR MH 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (ORMH 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (ORMH 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.

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Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands

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