Pregnancy Zone Protein is Increased in the Alzheimer's Disease Brain and Associates with Senile Plaques

Diana Nijholt, Linda IJsselstijn, Marcel van der Weiden, Pingpin Zheng, Peter Sillevis Smitt, Peter Koudstaal, Theo Luider, J.M. Kros

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Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering the blood stream during the early phase of the disease. Here we investigate the possible involvement of PZP in human AD pathogenesis. We observed increased PZP immunoreactivity in AD postmortem brain cortex compared to non-demented controls. In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons. Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.
Original languageUndefined/Unknown
Pages (from-to)227-238
Number of pages12
JournalJournal of Alzheimers Disease
Issue number1
Publication statusPublished - 2015

Research programs

  • EMC COEUR-09
  • EMC MM-03-24-01
  • EMC MM-03-44-06

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