Pregnancy Zone Protein is Increased in the Alzheimer's Disease Brain and Associates with Senile Plaques

Diana Nijholt; Linda IJsselstijn; Marcel van der Weiden; Pingpin Zheng; Peter Sillevis Smitt; Peter Koudstaal; Theo Luider; J.M. Kros

doi:10.3233/JAD-131628

Pregnancy Zone Protein is Increased in the Alzheimer's Disease Brain and Associates with Senile Plaques

Diana Nijholt, Linda IJsselstijn, Marcel van der Weiden, Pingpin Zheng, Peter Sillevis Smitt, Peter Koudstaal, Theo Luider, J.M. Kros

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering the blood stream during the early phase of the disease. Here we investigate the possible involvement of PZP in human AD pathogenesis. We observed increased PZP immunoreactivity in AD postmortem brain cortex compared to non-demented controls. In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons. Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.

Original language	Undefined/Unknown
Pages (from-to)	227-238
Number of pages	12
Journal	Journal of Alzheimers Disease
Volume	46
Issue number	1
DOIs	https://doi.org/10.3233/JAD-131628
Publication status	Published - 2015

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10.3233/JAD-131628

Cite this

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title = "Pregnancy Zone Protein is Increased in the Alzheimer's Disease Brain and Associates with Senile Plaques",

abstract = "Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering the blood stream during the early phase of the disease. Here we investigate the possible involvement of PZP in human AD pathogenesis. We observed increased PZP immunoreactivity in AD postmortem brain cortex compared to non-demented controls. In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons. Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.",

author = "Diana Nijholt and Linda IJsselstijn and {van der Weiden}, Marcel and Pingpin Zheng and {Sillevis Smitt}, Peter and Peter Koudstaal and Theo Luider and J.M. Kros",

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T1 - Pregnancy Zone Protein is Increased in the Alzheimer's Disease Brain and Associates with Senile Plaques

AU - Nijholt, Diana

AU - IJsselstijn, Linda

AU - van der Weiden, Marcel

AU - Zheng, Pingpin

AU - Sillevis Smitt, Peter

AU - Koudstaal, Peter

AU - Luider, Theo

AU - Kros, J.M.

PY - 2015

Y1 - 2015

N2 - Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering the blood stream during the early phase of the disease. Here we investigate the possible involvement of PZP in human AD pathogenesis. We observed increased PZP immunoreactivity in AD postmortem brain cortex compared to non-demented controls. In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons. Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.

AB - Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering the blood stream during the early phase of the disease. Here we investigate the possible involvement of PZP in human AD pathogenesis. We observed increased PZP immunoreactivity in AD postmortem brain cortex compared to non-demented controls. In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons. Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.

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DO - 10.3233/JAD-131628

M3 - Article

SN - 1387-2877

VL - 46

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JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

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