Prenatal assessment of brain malformations on neuroimaging: an expert panel review

Ivana Pogledic*, Kshitij Mankad, Mariasavina Severino, Tally Lerman-Sagie, Andras Jakab, Efrat Hadi, Anna C. Jansen, Nadia Bahi-Buisson, Natalya Di Donato, Renske Oegema, Christian Mitter, Ivan Capo, Matthew T. Whitehead, Parthiv Haldipur, Grazia Mancini, Thierry A. G. M. Huisman, Andrea Righini, Bill Dobyns, James A. Barkovich, Natasa Jovanov MilosevicGregor Kasprian, Maarten Lequin

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation.<br /> This expert panel review is written with the central aim of providing an easy-to-understand road map to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. For every developmental stage, the utility of each available neuroimaging modality, including prenatal multiplanar neuro sonography, anatomical MRI and advanced MRI techniques, as well as further insights from post-mortem imaging, has been highlighted.
Original languageEnglish
Article numberawae253
Pages (from-to)3982-4002
Number of pages21
JournalBrain
Volume147
Issue number12
DOIs
Publication statusPublished - 1 Nov 2024

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