Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation

C. A.J. Oudmaijer; R. W.F. de Bruin; L. S.S. Ooms; J. W. Selten; E. van Straalen; G. Ambagtsheer; T. Terkivatan; J. N.M. IJzermans

doi:10.1016/j.jff.2024.106161

Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation

C. A.J. Oudmaijer^*, R. W.F. de Bruin^*, L. S.S. Ooms, J. W. Selten, E. van Straalen, G. Ambagtsheer, T. Terkivatan, J. N.M. IJzermans^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Introduction:

Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a surgical procedure has not been investigated.

Objective:

To explore the effect of SFN in living kidney donors on the postoperative inflammatory response and recovery.

Methods:

We performed a double-blind randomised controlled trial where donors followed a SFN-enriched (8 mg) preoperative diet.

Results:

A total of 42 donors were included, there were no significant differences at baseline. Postoperative inflammatory response was consistent among both arms and subjective recovery showed no significant difference. Findings regarding postoperative kidney function suggest no consistently significant impact.

Discussion:

A well-defined SFN-enriched diet did not have anti-inflammatory or a clinically relevant effect on the outcome. Due to the complexity of dietary modification of the inflammatory response, additional research is needed.

Original language	English
Article number	106161
Journal	Journal of Functional Foods
Volume	116
DOIs	https://doi.org/10.1016/j.jff.2024.106161
Publication status	Published - May 2024

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Publisher Copyright:
© 2024 The Author(s)

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Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantationFinal published version, 2.71 MBLicence: CC BY

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Oudmaijer, C. A. J., de Bruin, R. W. F., Ooms, L. S. S., Selten, J. W., van Straalen, E., Ambagtsheer, G., Terkivatan, T., & IJzermans, J. N. M. (2024). Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation. Journal of Functional Foods, 116, Article 106161. https://doi.org/10.1016/j.jff.2024.106161

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title = "Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation",

abstract = "Introduction: Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a surgical procedure has not been investigated. Objective: To explore the effect of SFN in living kidney donors on the postoperative inflammatory response and recovery. Methods: We performed a double-blind randomised controlled trial where donors followed a SFN-enriched (8 mg) preoperative diet. Results:A total of 42 donors were included, there were no significant differences at baseline. Postoperative inflammatory response was consistent among both arms and subjective recovery showed no significant difference. Findings regarding postoperative kidney function suggest no consistently significant impact. Discussion: A well-defined SFN-enriched diet did not have anti-inflammatory or a clinically relevant effect on the outcome. Due to the complexity of dietary modification of the inflammatory response, additional research is needed.",

author = "Oudmaijer, {C. A.J.} and {de Bruin}, {R. W.F.} and Ooms, {L. S.S.} and Selten, {J. W.} and {van Straalen}, E. and G. Ambagtsheer and T. Terkivatan and IJzermans, {J. N.M.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = may,

doi = "10.1016/j.jff.2024.106161",

language = "English",

volume = "116",

journal = "Journal of Functional Foods",

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T1 - Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation

AU - Oudmaijer, C. A.J.

AU - de Bruin, R. W.F.

AU - Ooms, L. S.S.

AU - Selten, J. W.

AU - van Straalen, E.

AU - Ambagtsheer, G.

AU - Terkivatan, T.

AU - IJzermans, J. N.M.

PY - 2024/5

Y1 - 2024/5

N2 - Introduction: Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a surgical procedure has not been investigated. Objective: To explore the effect of SFN in living kidney donors on the postoperative inflammatory response and recovery. Methods: We performed a double-blind randomised controlled trial where donors followed a SFN-enriched (8 mg) preoperative diet. Results:A total of 42 donors were included, there were no significant differences at baseline. Postoperative inflammatory response was consistent among both arms and subjective recovery showed no significant difference. Findings regarding postoperative kidney function suggest no consistently significant impact. Discussion: A well-defined SFN-enriched diet did not have anti-inflammatory or a clinically relevant effect on the outcome. Due to the complexity of dietary modification of the inflammatory response, additional research is needed.

AB - Introduction: Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a surgical procedure has not been investigated. Objective: To explore the effect of SFN in living kidney donors on the postoperative inflammatory response and recovery. Methods: We performed a double-blind randomised controlled trial where donors followed a SFN-enriched (8 mg) preoperative diet. Results:A total of 42 donors were included, there were no significant differences at baseline. Postoperative inflammatory response was consistent among both arms and subjective recovery showed no significant difference. Findings regarding postoperative kidney function suggest no consistently significant impact. Discussion: A well-defined SFN-enriched diet did not have anti-inflammatory or a clinically relevant effect on the outcome. Due to the complexity of dietary modification of the inflammatory response, additional research is needed.

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VL - 116

JO - Journal of Functional Foods

JF - Journal of Functional Foods

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ER -

Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation

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