Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation

A. M.W.J. Schols*, P. B. Soeters, A. M.C. Dingemans, R. Mostert, P. J. Frantzen, E. F.M. Wouters

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

582 Citations (Scopus)

Abstract

Prevalence and characteristics of nutritional depletion were established by body composition measurements in 255 COPD patients in stable clinical condition admitted to a pulmonary rehabilitation center. Depletion of body weight, fat-free mass (using bioelectrical resistance measurements), and muscle mass [from creatinine height index (CHI) and midarm muscle circumference] was most pronounced (40 to 50%) in patients suffering from chronic hypoxemia and in normoxemic patients with severe airflow obstruction (FEV1 < 35%) but also occurred in ± 25% of patients with moderate airflow obstruction. Classification of the patients in four groups by body weight and fat-free mass revealed that depletion of fat-free mass may occur in normal- weight COPD patients (Group 3). These patients also exhibit a decreased CHI (61 ± 21%, mean ± SD) and suffer from physical impairment (12-min walking distance, WD, 532 ± 152 m) to an even greater degree than underweight patients with relative preservation of fat-free mass (Group 2) (CHI = 73 ± 16%; WD = 744 ± 233 m). No systematic differences were established between the four groups in serum protein concentrations or medication use. We conclude that fat-free mass is a better indicator of body mass depletion than body weight. Classification of COPD patients by body weight and fat-free mass may have consequences for planning and interpretation of intervention strategies, particularly in Group 2 and 3 patients.

Original languageEnglish
Pages (from-to)1151-1156
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume147
Issue number5
DOIs
Publication statusPublished - 1993
Externally publishedYes

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