Prevalence and molecular mechanism of macrolide resistance in beta-haemolytic streptococci in The Netherlands

C C Van Leer Buter; J W Mouton; C H W Klaassen; C M A Handgraaf; S Sunnen; W J G Melchers; P D J Sturm

doi:10.1016/j.ijantimicag.2010.02.010

Prevalence and molecular mechanism of macrolide resistance in beta-haemolytic streptococci in The Netherlands

C C Van Leer Buter, J W Mouton, C H W Klaassen, C M A Handgraaf, S Sunnen, W J G Melchers, P D J Sturm

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Abstract

The prevalence of resistance to erythromycin and clindamycin as well as the presence of the resistance genes mef(A), mef(E), erm(A) and erm(B) were determined in 1076 consecutive isolates of beta-haemolytic streptococci of Lancefield groups A (n=219), B (n=562),C (n=58) and G (n=237) collected during 2005 and 2006. The prevalence of macrolide resistance was highest in group C streptococci (6.9%), followed by group B (5.3%), group G (4.6%) and group A (1.4%). Eighty-eight percent of resistance was mediated by erm(A) and erm(B) genes. Macrolide resistance in beta-haemolytic streptococci in The Netherlands is low, but increasing macrolide resistance was observed in group B streptococci.

Original language	English
Pages (from-to)	590-2
Number of pages	3
Journal	International Journal of Antimicrobial Agents
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2010.02.010
Publication status	Published - Jun 2010
Externally published	Yes

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10.1016/j.ijantimicag.2010.02.010

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title = "Prevalence and molecular mechanism of macrolide resistance in beta-haemolytic streptococci in The Netherlands",

abstract = "The prevalence of resistance to erythromycin and clindamycin as well as the presence of the resistance genes mef(A), mef(E), erm(A) and erm(B) were determined in 1076 consecutive isolates of beta-haemolytic streptococci of Lancefield groups A (n=219), B (n=562),C (n=58) and G (n=237) collected during 2005 and 2006. The prevalence of macrolide resistance was highest in group C streptococci (6.9%), followed by group B (5.3%), group G (4.6%) and group A (1.4%). Eighty-eight percent of resistance was mediated by erm(A) and erm(B) genes. Macrolide resistance in beta-haemolytic streptococci in The Netherlands is low, but increasing macrolide resistance was observed in group B streptococci.",

author = "Buter, {C C Van Leer} and Mouton, {J W} and Klaassen, {C H W} and Handgraaf, {C M A} and S Sunnen and Melchers, {W J G} and Sturm, {P D J}",

year = "2010",

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language = "English",

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journal = "International Journal of Antimicrobial Agents",

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TY - JOUR

T1 - Prevalence and molecular mechanism of macrolide resistance in beta-haemolytic streptococci in The Netherlands

AU - Buter, C C Van Leer

AU - Mouton, J W

AU - Klaassen, C H W

AU - Handgraaf, C M A

AU - Sunnen, S

AU - Melchers, W J G

AU - Sturm, P D J

PY - 2010/6

Y1 - 2010/6

N2 - The prevalence of resistance to erythromycin and clindamycin as well as the presence of the resistance genes mef(A), mef(E), erm(A) and erm(B) were determined in 1076 consecutive isolates of beta-haemolytic streptococci of Lancefield groups A (n=219), B (n=562),C (n=58) and G (n=237) collected during 2005 and 2006. The prevalence of macrolide resistance was highest in group C streptococci (6.9%), followed by group B (5.3%), group G (4.6%) and group A (1.4%). Eighty-eight percent of resistance was mediated by erm(A) and erm(B) genes. Macrolide resistance in beta-haemolytic streptococci in The Netherlands is low, but increasing macrolide resistance was observed in group B streptococci.

AB - The prevalence of resistance to erythromycin and clindamycin as well as the presence of the resistance genes mef(A), mef(E), erm(A) and erm(B) were determined in 1076 consecutive isolates of beta-haemolytic streptococci of Lancefield groups A (n=219), B (n=562),C (n=58) and G (n=237) collected during 2005 and 2006. The prevalence of macrolide resistance was highest in group C streptococci (6.9%), followed by group B (5.3%), group G (4.6%) and group A (1.4%). Eighty-eight percent of resistance was mediated by erm(A) and erm(B) genes. Macrolide resistance in beta-haemolytic streptococci in The Netherlands is low, but increasing macrolide resistance was observed in group B streptococci.

U2 - 10.1016/j.ijantimicag.2010.02.010

DO - 10.1016/j.ijantimicag.2010.02.010

M3 - Article

C2 - 20353884

SN - 0924-8579

VL - 35

SP - 590

EP - 592

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 6

ER -

Prevalence and molecular mechanism of macrolide resistance in beta-haemolytic streptococci in The Netherlands

Abstract

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