Prevalence and Severity of Diabetic Retinopathy in Patients with Macular Telangiectasia Type 2

Saskia H.M. van Romunde*, Charlotte M. van der Sommen, José P. Martinez Ciriano, Johannes R. Vingerling, Suzanne Yzer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To study the prevalence and severity of diabetic retinopathy (DR) in patients with macular telangiectasia type 2 (MacTel 2). Design: Retrospective case series. Participants: Patients with a diagnosis of MacTel 2 treated at the Rotterdam Eye Hospital or Erasmus Medical Center between 2014 and 2018 were included. Methods: The following information was retrieved from patient files: demographics, history of diabetes mellitus and hypertension, presence of DR, and severity of DR, that is, mild, moderate, severe, or proliferative. Presence of diabetic macular edema (DME) was assessed using OCT. Main Outcome Measures: Presence and severity of DR. Results: Two hundred six eyes of 103 patients were included. At the onset of MacTel 2, the mean age was 61 years (standard deviation [SD], 9.8 years) and 64 (62%) were women. Mean follow-up was 71 months (SD, 60 months). Diabetes mellitus type 2 was present in 50 patients (49%) and hypertension was present in 47 patients (46%). Mild DR was present in 22 eyes (11%), of which 14 eyes (7%) showed signs at baseline and 8 eyes (4%) showed signs at a later time during follow-up. Ten eyes (5%) demonstrated remission of mild DR during follow-up. Both eyes (1%) in 1 patient progressed to moderate DR. Severe DR, proliferative DR, and DME did not occur. Conclusions: Although diabetes mellitus was highly prevalent among MacTel 2 patients, no patients showed severe or proliferative DR or DME. These findings suggest that MacTel 2 could have a protective effect on the progression of DR. We hypothesize that our results may be explained by the role of Müller cells in the development of MacTel 2 and DR, and therefore a link between both diseases warrants additional studies.

Original languageEnglish
Pages (from-to)999-1004
Number of pages6
JournalOphthalmology Retina
Volume5
Issue number10
DOIs
Publication statusPublished - Oct 2021

Bibliographical note

Funding Information:
The author(s) have no proprietary or commercial interest in any materials discussed in this article. No financial support was received for this study.

Publisher Copyright:
© 2021 American Academy of Ophthalmology

Fingerprint

Dive into the research topics of 'Prevalence and Severity of Diabetic Retinopathy in Patients with Macular Telangiectasia Type 2'. Together they form a unique fingerprint.

Cite this