Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

C. L. de Mol; A. L. Bruijstens; P. R. Jansen; M. H.G. Dremmen; Y. Y.M. Wong; A. van der Lugt; T. J.H. White; R. F. Neuteboom

doi:10.1177/1352458521989220

Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

C. L. de Mol, A. L. Bruijstens, P. R. Jansen, M. H.G. Dremmen, Y. Y.M. Wong, A. van der Lugt, T. J.H. White, R. F. Neuteboom^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

Original language	English
Pages (from-to)	1790-1793
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	27
Issue number	11
Early online date	22 Jan 2021
DOIs	https://doi.org/10.1177/1352458521989220
Publication status	Published - Oct 2021

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport.

Publisher Copyright:
© The Author(s), 2021.

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Prevalence of radiologically isolated syndrome in a pediatric population-based cohortFinal published version, 321 KBLicence: CC BY

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title = "Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis",

abstract = "Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.",

author = "{de Mol}, {C. L.} and Bruijstens, {A. L.} and Jansen, {P. R.} and Dremmen, {M. H.G.} and Wong, {Y. Y.M.} and {van der Lugt}, A. and White, {T. J.H.} and Neuteboom, {R. F.}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport. Publisher Copyright: {\textcopyright} The Author(s), 2021.",

year = "2021",

month = oct,

doi = "10.1177/1352458521989220",

language = "English",

volume = "27",

pages = "1790--1793",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

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TY - JOUR

T1 - Prevalence of radiologically isolated syndrome in a pediatric population-based cohort

T2 - A longitudinal description of a rare diagnosis

AU - de Mol, C. L.

AU - Bruijstens, A. L.

AU - Jansen, P. R.

AU - Dremmen, M. H.G.

AU - Wong, Y. Y.M.

AU - van der Lugt, A.

AU - White, T. J.H.

AU - Neuteboom, R. F.

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport. Publisher Copyright: © The Author(s), 2021.

PY - 2021/10

Y1 - 2021/10

N2 - Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

AB - Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

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SP - 1790

EP - 1793

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 11

ER -

Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

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