Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

C. L. de Mol; A. L. Bruijstens; P. R. Jansen; M. H.G. Dremmen; Y. Y.M. Wong; A. van der Lugt; T. J.H. White; R. F. Neuteboom

doi:10.1177/1352458521989220

Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

C. L. de Mol
, A. L. Bruijstens
, P. R. Jansen
, M. H.G. Dremmen
, Y. Y.M. Wong
, A. van der Lugt
, T. J.H. White
, R. F. Neuteboom^*

^*Corresponding author for this work

Amsterdam UMC

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

54 Downloads (Pure)

Abstract

Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

Original language	English
Pages (from-to)	1790-1793
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	27
Issue number	11
Early online date	22 Jan 2021
DOIs	https://doi.org/10.1177/1352458521989220
Publication status	Published - Oct 2021

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport.

Publisher Copyright:
© The Author(s), 2021.

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Prevalence of radiologically isolated syndrome in a pediatric population-based cohortFinal published version, 321 KBLicence: CC BY

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@article{53c5bb8c21a941a49bf3462cec842ed5,

title = "Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis",

abstract = "Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02\%; 95\% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.",

author = "\{de Mol\}, \{C. L.\} and Bruijstens, \{A. L.\} and Jansen, \{P. R.\} and Dremmen, \{M. H.G.\} and Wong, \{Y. Y.M.\} and \{van der Lugt\}, A. and White, \{T. J.H.\} and Neuteboom, \{R. F.\}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport. Publisher Copyright: {\textcopyright} The Author(s), 2021.",

year = "2021",

month = oct,

doi = "10.1177/1352458521989220",

language = "English",

volume = "27",

pages = "1790--1793",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "11",

}

TY - JOUR

T1 - Prevalence of radiologically isolated syndrome in a pediatric population-based cohort

T2 - A longitudinal description of a rare diagnosis

AU - de Mol, C. L.

AU - Bruijstens, A. L.

AU - Jansen, P. R.

AU - Dremmen, M. H.G.

AU - Wong, Y. Y.M.

AU - van der Lugt, A.

AU - White, T. J.H.

AU - Neuteboom, R. F.

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport. Publisher Copyright: © The Author(s), 2021.

PY - 2021/10

Y1 - 2021/10

N2 - Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

AB - Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

UR - https://www.scopus.com/pages/publications/85100035748

U2 - 10.1177/1352458521989220

DO - 10.1177/1352458521989220

M3 - Article

C2 - 33480814

AN - SCOPUS:85100035748

SN - 1352-4585

VL - 27

SP - 1790

EP - 1793

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 11

ER -

Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

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