Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer

Eider Talavera-Urquijo; Andrew R. Davies; Bas P.L. Wijnhoven

doi:10.1007/s13304-022-01315-4

Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer

Eider Talavera-Urquijo, Andrew R. Davies, Bas P.L. Wijnhoven^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.

Original language	English
Pages (from-to)	335-341
Number of pages	7
Journal	Updates in Surgery
Volume	75
Issue number	2
Early online date	16 Jul 2022
DOIs	https://doi.org/10.1007/s13304-022-01315-4
Publication status	Published - Feb 2023

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title = "Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer",

abstract = "A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.",

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AU - Talavera-Urquijo, Eider

AU - Davies, Andrew R.

AU - Wijnhoven, Bas P.L.

PY - 2023/2

Y1 - 2023/2

N2 - A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.

AB - A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2–20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.

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M3 - Review article

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SN - 2038-131X

VL - 75

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EP - 341

JO - Updates in Surgery

JF - Updates in Surgery

IS - 2

ER -

Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer

Abstract

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