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Price transparency of cancer medicines: a crucial step towards informed pricing negotiations in the European region

  • Julie Vancoppenolle
  • , Nora Franzen
  • , Cristina Andrianò
  • , Morten Baltzer Houlind
  • , Zora Ćetković
  • , Aniek Dane
  • , Albane Degrassat-Théas
  • , Anne M.P. Eldering-Heldens
  • , Martin J. Hug
  • , Holger Knoth
  • , Vito Ladisa
  • , Péter Vajda
  • , Ulrich Warnke
  • , Valesca Retèl
  • , Wim H. van Harten*
  • *Corresponding author for this work
  • Netherlands Cancer Institute
  • University of Twente
  • The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
  • IRCCS Istituto scientifico romagnolo per lo studio e la cura dei tumori - Meldola (FC)
  • Copenhagen University Hospital (Nordvest)
  • The Capital Region Pharmacy
  • University of Copenhagen
  • Clinical Center of Serbia
  • Université Paris Cité
  • Department of Pharmacy
  • University of Freiburg
  • Technische Universität Dresden
  • IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
  • Semmelweis University
  • Klinikum Ernst von Bergmann
  • Organization of European Cancer Institutes (OECI)

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: 

The increasing cost of cancer medicines is a growing concern for hospitals in the European region, leading to cost reduction strategies, such as price negotiations. The objective of this study is to compare actual prices and discounts of cancer medicines at hospital level across the European region. 

Methods: 

To report prices and discounts without compromising the hospitals’ anonymity, an anonymization pathway was developed. Pricing data of 15 cancer medicines in 2022 was collected through structured interviews with hospital staff and reference prices were derived from the IQVIA-MIDAS dataset. Descriptive analyses were used to demonstrate product and reference prices. Discounts were aggregated across countries and product types. Furthermore, the accuracy of the participants’ perceptions of their prices compared to others within their country was assessed. 

Results: 

23 hospitals from nine countries participated. To comply with the anonymization pathway, three countries were presented in general terms. The highest prices at hospital level were observed in France, followed by Serbia, Germany, Hungary and the Netherlands. Two Southern and one Northern European country had the lowest prices. When comparing them with their reference prices, Serbia reports the lowest discounts (−7%) and the Southern European countries the highest discounts (−38%). In addition, at least half of the hospitals had incorrect perceptions of their prices relative to others within their country, with some up to 22% higher than average. 

Discussion: 

Our study is one of few providing discounts and actual prices for 15 cancer medicines, revealing large price variations between and within countries. Additionally, reference prices often fail to provide an accurate indication of the actual price and hospitals have often misguided perceptions on their negotiation performance. Transparent, standardized reporting of prices and coordinated collaborations are essential to strengthen the bargaining power of hospitals and foster informed price negotiations.

Original languageEnglish
Article number1736741
JournalFrontiers in Pharmacology
Volume17
DOIs
Publication statusPublished - 9 Mar 2026

Bibliographical note

Publisher Copyright:
Copyright © 2026 Vancoppenolle, Franzen, Andrianò, Houlind, Ćetković, Dane, Degrassat-Théas, Eldering-Heldens, Hug, Knoth, Ladisa, Vajda, Warnke, Retèl and van Harten.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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