Primary pineal tumors: outcome and prognostic factors-a study from the Rare Cancer Network (RCN)

S Villa, RC Miller, M Krengli, Huda Abusaris, BG Baumert, S Servagi-Vernat, S Igdem, A Lucas, S Boluda, RO Mirimanoff

Research output: Contribution to journalArticleAcademic

16 Citations (Scopus)

Abstract

To better define outcome and prognostic factors in primary pineal tumors. Thirty-five consecutive patients from seven academic centers of the Rare Cancer Network diagnosed between 1988 and 2006 were included. Median age was 36 years. Surgical resection consisted of biopsy in 12 cases and resection in 21 (2 cases with unknown resection). All patients underwent radiotherapy and 12 patients received also chemotherapy. Histological subtypes were pineoblastoma (PNB) in 21 patients, pineocytoma (PC) in 8 patients and pineocytoma with intermediate differentiation in 6 patients. Six patients with PNB had evidence of spinal seeding. Fifteen patients relapsed (14 PNB and 1 PC) with PNB cases at higher risk (p = 0.031). Median survival time was not reached. Median disease-free survival was 82 months (CI 50 % 28-275). In univariate analysis, age younger than 36 years was an unfavorable prognostic factor (p = 0.003). P Age and dissemination at diagnosis influenced survival in our series. The prevalence of chronic toxicity suggests that new adjuvant strategies are advisable.
Original languageUndefined/Unknown
Pages (from-to)827-834
Number of pages8
JournalClinical & Translational Oncology
Volume14
Issue number11
DOIs
Publication statusPublished - 2012

Cite this