Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study

P Saeed, L Blank, D Selva, JG Wolbers, Peter Nowak, RB Geskus, E Weis, MP Mourits, J Rootman

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Background/aims To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods The clinical records of all patients were reviewed in a retrospective, observational, multicentre study. Results Thirty-four consecutive patients were included. Twenty-six women and eight men received conventional or stereotactic fractionated radiotherapy, and were followed for a median 58 (range 51-156) months. Fourteen eyes (41%) showed improved visual acuity of at least two lines on the Snellen chart. In 17 (50%) eyes, the vision stabilised, while deterioration was noted in three eyes (9%). The visual outcome was not associated with age at the time of radiotherapy (p=0.83), sex (p=0.43), visual acuity at the time of presentation (p=0.22) or type of radiotherapy (p=0.35). Optic disc swelling was associated with improved visual acuity (p<0.01) and 4/11 patients with optic atrophy also showed improvement. Long-term complications were dry eyes in five patients, cataracts in three, and mild radiation retinopathy in four. Conclusion Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects.
Original languageUndefined/Unknown
Pages (from-to)564-568
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number5
Publication statusPublished - 2010

Research programs

  • EMC OR-01-45-01

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