Procedural pain does not raise plasma levels of cortisol or catecholamines in adult intensive care patients after cardiac surgery

L van Gulik, SJGM Ahlers, Monique van Dijk, P Bruins, Marcel Meima, Yolanda de Rijke, HS Biemond-Moeniralam, Dick Tibboel, Catherijne Knibbe

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5 Citations (Scopus)


The gold standard for quantification of pain is a person's self-report. However, we need objective parameters for pain measurement when intensive care patients are not able to report pain themselves. An increase in pain is currently thought to coincide with an increase in stress hormones. This observational study investigated whether procedure-related pain is associated with an increase of plasma cortisol, adrenaline, and noradrenaline. In 59 patients receiving intensive care after cardiac surgery, cortisol, adrenaline, and noradrenaline plasma levels were measured immediately before and immediately after patients were turned for washing, with or without concurrent removal of drain tubes. Numeric rating scale scores were obtained before, during, and after the procedure. Unacceptably severe pain (numeric rating scale 4) was reported by seven (12%), 26 (44%), and nine (15%) patients, before, during and after the procedure, respectively. There was no statistically significant association between numeric rating scale scores and change in cortisol, adrenaline, and noradrenaline plasma levels during the procedure. Despite current convictions that pain coincides with an increase in stress hormones, procedural pain was not associated with a significant increase in plasma stress hormone levels in patients who had undergone cardiac surgery. Thus, plasma levels of cortisol, adrenaline, and noradrenaline seem unsuitable for further research on the measurement of procedural pain.
Original languageUndefined/Unknown
Pages (from-to)52-56
Number of pages5
JournalAnaesthesia & Intensive Care
Issue number1
Publication statusPublished - 2016

Research programs

  • EMC MGC-02-53-01-A
  • EMC MM-01-25-01
  • EMC MM-03-54-04-A

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