Product type and the risk of inhibitor development in nonsevere haemophilia A patients: a case-control study

INSIGHT consortium, Alice S van Velzen, Corien L Eckhardt, Marjolein Peters, Johannes Oldenburg, Marjon Cnossen, Ri Liesner, Massimo Morfini, Giancarlo Castaman, Simon McRae, Johanna G van der Bom, Karin Fijnvandraat

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Inhibitor development is a major complication of treatment with factor VIII concentrates in nonsevere haemophilia A. It has been suggested that plasma-derived factor VIII (FVIII) concentrates elicit fewer inhibitors than recombinant FVIII concentrates, but studies in severe haemophilia A patients have shown conflicting results. We designed a case-control study to investigate the clinical and genetic risk factors for inhibitor development in nonsevere haemophilia A patients. We investigated whether the type of FVIII concentrate was associated with inhibitor development in nonsevere haemophilia A patients. This nested case-control study includes 75 inhibitor patients and 223 controls, from a source population of the INSIGHT study, including all nonsevere haemophilia A patients (FVIII:C 2-40%) that were treated with FVIII concentrates in 33 European and one Australian centre. Cases and controls were matched for date of birth and cumulative number of exposure days (CED) to FVIII concentrate. A conditional logistic regression model was used to calculate unadjusted and adjusted odds ratios. No increased risk for inhibitor development was found for any type of FVIII concentrate; either when comparing recombinant FVIII concentrates to plasma-derived FVIII concentrates (adjusted odds ratio 0·96, 95% confidence interval (CI) 0·36-2·52) or for specific types of FVIII concentrates.

Original languageEnglish
Pages (from-to)1182-1191
Number of pages10
JournalBritish Journal of Haematology
Volume189
Issue number6
DOIs
Publication statusPublished - Jun 2020

Bibliographical note

© 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

Research programs

  • EMC MM-02-54-03

Fingerprint

Dive into the research topics of 'Product type and the risk of inhibitor development in nonsevere haemophilia A patients: a case-control study'. Together they form a unique fingerprint.

Cite this