PROGNOSIS: A VARIABLE PARAMETER. DYNAMIC PROGNOSTIC MODELING IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

M.P. van der Schroeff; Ewout Steyerberg; Marjan Wieringa; Ton Langeveld; J Molenaar; R.J. Baatenburg de Jong

doi:10.1002/hed.21693

PROGNOSIS: A VARIABLE PARAMETER. DYNAMIC PROGNOSTIC MODELING IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

M.P. van der Schroeff, Ewout Steyerberg, Marjan Wieringa, Ton Langeveld, J Molenaar, R.J. Baatenburg de Jong

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

Background. In general, the estimated prognosis of patients with cancer is based on patient characteristics known at the time of diagnosis and presented as if a lifetime verdict. However, the prognosis of patients with cancer who survive the first critical years changes, along with the prognosis for those with local or regional recurrences or distant metastases. Methods. This study concerns 2927 patients with a primary head and neck squamous cell carcinoma (HNSCC). We developed prognostic models after initial treatment and at different time points during follow-up. Results. The developed models show the effects of survival time, recurrences, and distant metastasis during follow-up. The C-statistics ranged from 0.76 to 0.69. Conclusion. Prognosis is dynamic: the passage of time and the occurrence of life events change the predicted probabilities of survival. The models enhance our insight in the effect of recurrences and metastasis during follow-up and could be used for better patient counseling. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 34-41, 2012

Original language	Undefined/Unknown
Pages (from-to)	34-41
Number of pages	8
Journal	Head & Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/hed.21693
Publication status	Published - 2012

Research programs

EMC NIHES-02-65-01
EMC OR-01-62-02

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hed.21693

http://hdl.handle.net/1765/34854

Cite this

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title = "PROGNOSIS: A VARIABLE PARAMETER. DYNAMIC PROGNOSTIC MODELING IN HEAD AND NECK SQUAMOUS CELL CARCINOMA",

abstract = "Background. In general, the estimated prognosis of patients with cancer is based on patient characteristics known at the time of diagnosis and presented as if a lifetime verdict. However, the prognosis of patients with cancer who survive the first critical years changes, along with the prognosis for those with local or regional recurrences or distant metastases. Methods. This study concerns 2927 patients with a primary head and neck squamous cell carcinoma (HNSCC). We developed prognostic models after initial treatment and at different time points during follow-up. Results. The developed models show the effects of survival time, recurrences, and distant metastasis during follow-up. The C-statistics ranged from 0.76 to 0.69. Conclusion. Prognosis is dynamic: the passage of time and the occurrence of life events change the predicted probabilities of survival. The models enhance our insight in the effect of recurrences and metastasis during follow-up and could be used for better patient counseling. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 34-41, 2012",

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doi = "10.1002/hed.21693",

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volume = "34",

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T1 - PROGNOSIS: A VARIABLE PARAMETER. DYNAMIC PROGNOSTIC MODELING IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

AU - van der Schroeff, M.P.

AU - Steyerberg, Ewout

AU - Wieringa, Marjan

AU - Langeveld, Ton

AU - Molenaar, J

AU - Baatenburg de Jong, R.J.

PY - 2012

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N2 - Background. In general, the estimated prognosis of patients with cancer is based on patient characteristics known at the time of diagnosis and presented as if a lifetime verdict. However, the prognosis of patients with cancer who survive the first critical years changes, along with the prognosis for those with local or regional recurrences or distant metastases. Methods. This study concerns 2927 patients with a primary head and neck squamous cell carcinoma (HNSCC). We developed prognostic models after initial treatment and at different time points during follow-up. Results. The developed models show the effects of survival time, recurrences, and distant metastasis during follow-up. The C-statistics ranged from 0.76 to 0.69. Conclusion. Prognosis is dynamic: the passage of time and the occurrence of life events change the predicted probabilities of survival. The models enhance our insight in the effect of recurrences and metastasis during follow-up and could be used for better patient counseling. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 34-41, 2012

AB - Background. In general, the estimated prognosis of patients with cancer is based on patient characteristics known at the time of diagnosis and presented as if a lifetime verdict. However, the prognosis of patients with cancer who survive the first critical years changes, along with the prognosis for those with local or regional recurrences or distant metastases. Methods. This study concerns 2927 patients with a primary head and neck squamous cell carcinoma (HNSCC). We developed prognostic models after initial treatment and at different time points during follow-up. Results. The developed models show the effects of survival time, recurrences, and distant metastasis during follow-up. The C-statistics ranged from 0.76 to 0.69. Conclusion. Prognosis is dynamic: the passage of time and the occurrence of life events change the predicted probabilities of survival. The models enhance our insight in the effect of recurrences and metastasis during follow-up and could be used for better patient counseling. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 34-41, 2012

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